CBL1337F

Anti-PECAM-1 Antibody, clone 390, FITC conjugated

Name: Anti-PECAM-1 Antibody, clone 390, FITC conjugated
Brand: MM

clone 390, Chemicon^®, from rat

Synonym(s):

CD31

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-PECAM-1 Antibody, clone 390, FITC conjugated, clone 390, Chemicon^®, from rat

biological source

rat

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

390, monoclonal

species reactivity

mouse

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG2aκ

NCBI accession no.

NM_000442.3

UniProt accession no.

P16284

shipped in

wet ice

target post-translational modification

unmodified

Application

Flow Cytometry: = 1 μg per 10e6 cells in 100 μL volume

Immunohistochemistry: acteone fixed frozen tissue sections.

Optimal working dilutions must be determined by the end user.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

This Anti-PECAM-1 Antibody, clone 390, FITC conjugated is validated for use in FC, IH for the detection of PECAM-1.

Biochem/physiol Actions

CBL1337 recognizes mouse PECAM-1, a 130-140 kDa type 1 integral membrane glycoprotein. This antibody has been shown to inhibit the aggregation of L cells transfected with a variant form of PECAM-1 (DeLisser, 1993).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

PECAM-1 is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.

Immunogen

Mouse leukocyte cell line 32D

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Purified immunoglobulin conjugated to fluorescein. Liquid in in phosphate buffered saline containing 0.1% sodium azide.

Preparation Note

Maintain at 2°-8°C for up to 12 months from date of receipt. DO NOT FREEZE.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.

Sofia Urner et al.

The EMBO journal, 38(2) (2018-12-07)

Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here

Mechanoinduction of lymph vessel expansion.

Lara Planas-Paz et al.

The EMBO journal, 31(4), 788-804 (2011-12-14)

In the mammalian embryo, few mechanical signals have been identified to influence organ development and function. Here, we report that an increase in the volume of interstitial or extracellular fluid mechanically induces growth of an organ system, that is, the

Global Trade Item Number

SKU	GTIN
CBL1337F	04053252278334

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