CBL458

Anti-CD49f Antibody, clone 4F10

Name: Anti-CD49f Antibody, clone 4F10
Brand: MM

clone 4F10, Chemicon^®, from mouse

Synonym(s):

Integrin alpha6

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-CD49f Antibody, clone 4F10, clone 4F10, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

4F10, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2b

NCBI accession no.

NM_000210.2
NM_001079818.1

UniProt accession no.

P23229

shipped in

wet ice

target post-translational modification

unmodified

Application

Immunohistological studies on frozen sections

Immunoprecipitation of the laminin receptor

Flow Cytometry

Optimal working dilutions must be determined by the end user.

Research Category
Cell Structure

Research Sub Category
Integrins

This Anti-CD49f Antibody, clone 4F10 is validated for use in FC, IP, IH for the detection of CD49f.

Biochem/physiol Actions

This antibody is specific to the integrin alpha6 chain which is expressed on epithelial and endothelial basement membrane. The VLA alpha6 chain, which consists of a single disulphide linked 120 kDa subunit and a small doublet subunit of 25/30 kDa, is non covalently associated with the VLA beta-chain (CD29) in VLA-6 or alpha6/beta1 complex or with integrin beta4 chain (alpha6/beta4).

The antigen is also expressed on platelets, monocytes, thymocytes and T lymphocytes.

FUSION PARTNER: NS1 myeloma cell line

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Cell line SW/222 (Human colorectal carcinoma)

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: MAB2254

Physical form

Format: Purified

The monoclonal was purified by protein A affinity chromatography and is presented as a liquid in phosphate buffered saline containing 10mM sodium azide and 1 mg/mL bovine serum albumin.

Preparation Note

Store an 2-8°C for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C. Avoid repeated freeze-thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mechanical stimulation induces rapid fibroblast proliferation and accelerates the early maturation of human skin substitutes.

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Biomaterials, 273, 120779-120779 (2021-05-02)

The clinical treatment of large, full-thickness skin injuries with tissue-engineered autologous dermo-epidermal skin substitutes is an emerging alternative to split-thickness skin grafting. However, their production requires about one month of in vitro cell and tissue culture, which is a significant

EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.

Bryan W Day et al.

Cancer cell, 23(2), 238-248 (2013-02-16)

Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in GBM and, in particular, in the most

Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway.

Klees, RF; Salasznyk, RM; Kingsley, K; Williams, WA; Boskey, A; Plopper, GE

Molecular Biology of the Cell null

Global Trade Item Number

SKU	GTIN
CBL458	04053252737435

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