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FCABS165A6

Sigma-Aldrich

Milli-Mark® Anti-MAPK 1/2 (tERK) Antibody, Alexa Fluor 647 Conjugate

Milli-Mark®, from rabbit

Synonym(s):

Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, MAP kinase isoform p44, p44, MAPK, Microtubule-associated protein 2 kinase, MNK1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

ALEXA FLUOR™ 647

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

NCBI accession no.

NP_059043

UniProt accession no.

P21708

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MAPK1(5594)

General description

43 kDa Calculated
The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called MAPK1 and MAPK2, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or MAPK1/2. The MAPK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of MAPK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand.

Immunogen

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to rat MAPK 1/2 at the C-terminus.

Application

Milli-Mark Anti-MAPK 1/2 (tERK) Antibody, Alexa Fluor 647 Conjugate detects level of MAPK 1/2 (tERK) & has been published & validated for use in FC.
Research Category
Signaling
Research Sub Category
MAP Kinases

Biochem/physiol Actions

Antibody recognizes MAPK1/2. C-terminus.

Physical form

Protein A purified
Purified rabbit polyclonal antibody conjugated to Alexa Fluor 647 in PBS buffer with 15mg/mL BSA and 0.1% Sodium Azide

Preparation Note

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.

Analysis Note

Control
Jurkat cells
Evaluated by flow cytometry using Jurkat cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
FCABS165A604053252411984

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