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Merck

FCMAB110P

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

clone 10H11.E12, from mouse, PE

Synonym(s):

A-T, mutated

AT mutated

TEL1, telomere maintenance 1, homolog

ataxia telangiectasia mutated

ataxia telangiectasia mutated (includes complementation groups A, C and D)

ataxia telangiectasia mutated protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate, clone 10H11.E12, from mouse, PE

biological source

mouse

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

10H11.E12, monoclonal

species reactivity

rat, mouse, human

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NP_000042

UniProt accession no.

Q13315

shipped in

wet ice

target post-translational modification

phosphorylation (pSer1981)

Quality Level

100

Gene Information

human ... ATM(472)

Related Categories

Physical form

Purified mouse monoclonal IgG1κ conjugated to phycoerythrin in PBS with less than 0.09% sodium azide and 15 mg/mL BSA.

Immunogen

KLH-conjugated, synthetic peptide corresponding to human ATM phosphorylated at Ser1981.
Epitope: Phosphorylated at and around Ser1981

Analysis Note

Control
Irradiated HeLa cells
Evaluated by Flow Cytometry with HeLa cells.

Application

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate detects level of phospho-ATM (Ser1981) & has been published & validated for use in FC.

Biochem/physiol Actions

Antibody recognizes ATM phosphorylated at Ser1981.
Predicted to cross-react with rat based on sequence homology

General description

N-terminal c-Myc, GST-tagged, recombinant human Cardiac Troponin I full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.
~370 kDa Calculated

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yiting Lim et al.
International journal of radiation oncology, biology, physics, 84(3), 800-806 (2012-03-27)
We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses
S Masneri et al.
Stem cell research, 41, 101596-101596 (2019-11-02)
Using a Sendai Virus based vector delivering Yamanaka Factors, we generated induced Pluripotent Stem Cells (iPSCs) from peripheral blood mononuclear cells of a patient affected by Ataxia Telangiectasia (AT), caused by a novel homozygous deletion in ATM, spanning exons 5-7.
Sabrina Fritah et al.
Cancers, 12(9) (2020-09-16)
Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, and failed to provide effective therapeutic targets. Long noncoding

Global Trade Item Number

SKUGTIN
FCMAB110P04053252405143

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