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Merck

HGAMMAG-301K

MILLIPLEX® Human Immunoglobulin Isotyping Panel

Configurable Human Immunoglobulin Isotyping 6-Plex Panel

Synonym(s):

Human Ig isotype multiplex panel, Human immune globulin multiplex panel, Human immunoglobulin multiplex kit, Luminex® human immunoglobulin immunoassay, Millipore Human immunoglobulin panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

Key Documents

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species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 88-99%, sensitivity: 0.08 ng/mL
(IgG4), sensitivity: 0.09 ng/mL
(IgG3), sensitivity: 0.47 ng/mL
(IgM), sensitivity: 1.5 ng/mL
(IgA), sensitivity: 10 ng/mL
(IgG1), sensitivity: 85 ng/mL
(IgG2), standard curve range: 0.2-150 ng/mL
(IgG3), standard curve range: 0.4-300 ng/mL
(IgG4), standard curve range: 14-10,000 ng/mL
(IgG1), standard curve range: 2.1-1,500 ng/mL
(IgA), standard curve range: 3.4-2,500 ng/mL
(IgM), standard curve range: 41-30,000 ng/mL
(IgG2)

technique(s)

multiplexing: suitable

input

cell culture supernatant
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Produced by plasma cells and lymphocytes, immunoglobulins (antibodies) are critically involved in immune response, attaching to antigens, and playing a role in their destruction. Immunoglobulins (Ig) can be classified by isotype, classes that differ in function and antigen response due to structure variability. Five major isotypes have been identified in placental mammals: IgM, IgG, IgA, IgE and IgD (B-cell receptor) – all found in normal individuals. Immunoglobulin-deficiency disorders, such as autoimmune disease, some GI conditions, and malignancies, are characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of immunoglobulin classes. In addition, isotyping applications include analyzing hybridomas during antibody generation and vaccine development.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: IgG1, IgG2, IgG3, IgG4, IgA, IgM

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive Isotyping: Measures multiple human immunoglobulin classes and subclasses (IgG1, IgG2, IgG3, IgG4, IgA, IgM) in a single assay, providing a complete overview of the immune response.
  • Enhanced Research Capabilities: By providing a detailed analysis of immunoglobulin isotypes, researchers can better understand immune responses in various conditions, including autoimmune diseases and malignancies.
  • Quick Turnaround: Assay run time of just one day allows for timely results, facilitating faster research progress.
  • Standardization and Controls: Includes multi-immunoglobulin standard and positive control to ensure assay reliability and accuracy.
  • Increased Productivity: The multiplex nature of the assay significantly reduces the time and resources needed to assess multiple analytes, allowing researchers to focus on data interpretation and application.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brian K McFarlin et al.
Journal of dietary supplements, 10(3), 171-183 (2013-08-10)
Strenuous exercise, such as running a marathon, is known to suppress mucosal immunity for up to 24 hr, which can increase the risk of developing an upper respiratory tract infection (URTI) and reduced performance capacity (Allgrove JE, Geneen L, Latif
Patricia S Grace et al.
Frontiers in immunology, 12, 679973-679973 (2021-07-23)
With an estimated 25% of the global population infected with Mycobacterium tuberculosis (Mtb), tuberculosis (TB) remains a leading cause of death by infectious diseases. Humoral immunity following TB treatment is largely uncharacterized, and antibody profiling could provide insights into disease
Jiong Wang et al.
Frontiers in immunology, 12, 696370-696370 (2021-08-14)
The COVID-19 pandemic is caused by SARS-CoV-2, a novel zoonotic coronavirus. Emerging evidence indicates that preexisting humoral immunity against other seasonal human coronaviruses (HCoVs) plays a critical role in the specific antibody response to SARS-CoV-2. However, current work to assess
Kristin L Boswell et al.
PLoS pathogens, 10(1), e1003853-e1003853 (2014-02-06)
The interaction between follicular T helper cells (TFH) and B cells in the lymph nodes and spleen has a major impact on the development of antigen-specific B cell responses during infection or vaccination. Recent studies described a functional equivalent of
Sarah H Pedersen et al.
Clinical nutrition (Edinburgh, Scotland), 35(4), 871-879 (2015-06-18)
Understanding mature breastmilk immunology may benefit infants chronically exposed to infectious pathogens in resource-limited regions. This prospective rural/semi-rural Tanzanian cohort of women (n = 102 at delivery; 38% HIV-positive) and their infants (n = 102) investigated breastmilk, maternal and infant serum immunoglobulins (IgA/IgG1-4/IgM) and
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Global Trade Item Number

SKUGTIN
HGAMMAG-301K-0604053252804878
HGAMMAG-301K-03C04055977100310
HGAMMAG-301K-04C04055977108286
HGAMMAG-301K-0404053252804854
HGAMMAG-301K-0304053252804847
HGAMMAG-301K-05C04055977100327
HGAMMAG-301K-0504053252804861
HGAMMAG-301K-06C04055977106763
HGAMMAG-301K-01C04055977100303
HGAMMAG-301K-0204053252804830
HGAMMAG-301K-0104053252804823
HGAMMAG-301K-02C04055977106756

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