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Merck

HMMP1MAG-55K

MILLIPLEX® Human MMP Panel

Configurable Human MMP 3-Plex Panel

Synonym(s):

Human matrix metalloproteinase multiplex kit, Luminex® Human MMP immunoassay, Millipore human MMP panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

standard curve range: 146-150,000 pg/mL
(MMP-3), standard curve range: 58-60,000 pg/mL
(MMP-13), standard curve range: 98-100,000 pg/mL
(MMP-12)

technique(s)

multiplexing: suitable

input

cell culture supernatant
serum
urine

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 3 analytes in human serum, plasma, urine, and cell culture supernatants.

Analytes included: MMP-3, MMP-12, MMP-13

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Targeted 3-Plex Design: Focused Luminex® xMAP® magnetic bead platform specifically quantitates MMP-3, MMP-12, and MMP-13 simultaneously, providing concentrated analysis of key tissue remodeling enzymes in a single well.
  • Broad Sample Compatibility: Analytically verified across serum, plasma, urine, tissue/cell lysates, and culture supernatants with neat sample processing - no dilution required for most applications.
  • Streamlined Workflow: Optimized 3-analyte configuration delivers fast, one-day results while maximizing sample conservation and minimizing hands-on time for research studies.
  • Precision Research Focus: Concentrate on three critical MMPs involved in tissue degradation and remodeling processes, enabling targeted investigation of specific pathological pathways in inflammation research.
  • Mechanistic Research Applications: Target MMPs specifically associated with collagen degradation (MMP-3, MMP-13) and elastin breakdown (MMP-12) to investigate tissue destruction mechanisms in arthritis, cardiovascular, and pulmonary research.

General description

MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karolina Minta et al.
Scientific reports, 10(1), 18075-18075 (2020-10-24)
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives
Karolina Minta et al.
Clinica chimica acta; international journal of clinical chemistry, 512, 74-83 (2020-12-05)
Altered levels of two extracellular matrix (ECM) proteoglycans, brevican and neurocan, have been found in brain injury models; however, their proteolytic processing in traumatic brain injury (TBI) remains unexplored. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a possible
Saritha Tantravedi et al.
Oncotarget, 8(70), 115280-115289 (2018-02-01)
When crypt stem cells of the gastrointestinal tract become injured, the result is increased synthesis of pro-inflammatory cytokines and matrix metalloproteinases by their progeny - the colonic epithelium. Chronic inflammation of the gastrointestinal tract is a characteristic of inflammatory bowel
Yingqian Zhang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2963-2974 (2016-11-26)
Blood-brain barrier (BBB) disruption plays an important role in pathophysiological progress of ischemic stroke. However, our knowledge of the dynamic change of BBB permeability and its mechanism remains limited. In the current study, we used a non-human primate (NHP) MCAO
Charbel Moussa et al.
Journal of neuroinflammation, 14(1), 1-1 (2017-01-15)
Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. For this retrospective study
View All Related Papers

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Global Trade Item Number

SKUGTIN
HMMP1MAG-55K-0304053252909511
HMMP1MAG-55K-0204053252909504
HMMP1MAG-55K-0104053252909498

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