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Merck

HMMP2MAG-55K

MILLIPLEX® Human MMP Panel

Configurable Human MMP 5-Plex Panel

Synonym(s):

Human matrix metalloproteinase multiplex kit, Luminex® Human MMP immunoassay, Millipore human MMP panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 72-98%, standard curve range: 14-10,000 pg/mL
(MMP-9), standard curve range: 27-20,000 pg/mL
(MMP-1), standard curve range: 27-20,000 pg/mL
(MMP-10), standard curve range: 548-400,000 pg/mL
(MMP-7), standard curve range: 68-50,000 pg/mL
(MMP-2)

technique(s)

multiplexing: suitable

input

cell culture supernatant
urine
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in human serum, plasma, urine, and cell culture supernatants.

Analytes included: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive MMP Coverage: Key MMPs involved in inflammation, cardiovascular disease, and cancer research for complete MMP/TIMP pathway analysis.
  • Advanced Multiplex Technology: Luminex® xMAP® magnetic bead platform quantitates 5 critical MMPs (MMP-1, -2, -7, -9, -10) simultaneously in one well with superior speed and sensitivity in a single day.
  • Flexible Design: Configure your panel by selecting specific analytes and scale from small studies to large trials, supporting diverse inflammation and immunology research applications.
  • Sample Versatility: Compatible with human serum, plasma, urine, tissue/cell lysates, and culture supernatants using optimized dilutions that conserves sample volume for research applications.
  • Research Applications: Target disease-relevant biomarkers in arthritis, cardiovascular disease, and cancer research to support biomarker discovery, mechanistic studies, and translational research programs.
  • Research-Grade Quality: Verified for research use with standardized protocols, comprehensive technical support, and quality systems designed for multi-laboratory research collaborations.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yu Yue et al.
BioMed research international, 2020, 2961742-2961742 (2020-07-01)
The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial
Mittal Jasoliya et al.
Brain sciences, 10(6) (2020-06-14)
Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predictive of targeted drugs' response
Larissa Berloffa Belardin et al.
Scientific reports, 9(1), 903-903 (2019-01-31)
Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)
M R Milone et al.
Cell death & disease, 4, e641-e641 (2013-05-25)
The nitrogen-containing bisphosphonates (N-BP) zoledronic acid (ZOL) inhibits osteoclast-mediated bone resorption, and it is used to prevent skeletal complications from bone metastases. ZOL has also demonstrated anticancer activities in preclinical models and, recently, in cancer patients, highlighting the interest in
Karolina Minta et al.
Scientific reports, 10(1), 18075-18075 (2020-10-24)
Matrix metalloproteinases (MMPs) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins. Increased expression of MMPs have been described in traumatic brain injury (TBI) and may contribute to additional tissue injury and blood-brain barrier damage. The objectives
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96 well Template Single
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Global Trade Item Number

SKUGTIN
HMMP2MAG-55K-0404053252798993
HMMP2MAG-55K-0104053252795961
HMMP2MAG-55K-0504053252799006
HMMP2MAG-55K-0204053252795978
HMMP2MAG-55K-0304053252795985

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