MAB10050

Anti-CCT-beta Antibody, clone F39 P7 F11

Name: Anti-CCT-beta Antibody, clone F39 P7 F11
Brand: MM

clone F39 P7 F11, Chemicon^®, from mouse

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-CCT-beta Antibody, clone F39 P7 F11, clone F39 P7 F11, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

F39 P7 F11, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_006422

UniProt accession no.

Q9Y5K3

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... PCYT1B(9468)

Analysis Note

Control
Tested on Hela cell lysate

Application

Research Category
Protein Trafficking

Research Sub Category
Chaperones

This Anti-CCT-beta Antibody, clone F39 P7 F11 is validated for use in WB for the detection of CCT-beta.

Western Blot Analysis: 0.1 - 0.5 ug/mL of this antibody detects a 60 kDa band of CCT-beta in HeLa cell lysate.

Optimal antibody dilution must be determined by end-user.

Biochem/physiol Actions

CCT-beta

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

60 kDa

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.

Immunogen

Synthetic Peptide corresponding to the C-Terminus of Human CCT-beta

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Protein A purified

Purified mouse monoclonal IgG2aκ in buffer containing PBS and 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators.

Heba Ghozlan et al.

Frontiers in oncology, 11, 663877-663877 (2021-05-18)

Uncontrolled proliferation as a result of dysregulated cell cycling is one of the hallmarks of cancer. Therapeutically targeting pathways that control the cell cycle would improve patient outcomes. However, the development of drug resistance and a limited number of inhibitors

Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis.

Anne E Showalter et al.

Scientific reports, 10(1), 798-798 (2020-01-23)

Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for cancer development. CCT is expressed in diverse cancers and could be an ideal therapeutic target if not for the fact that the complex

Global Trade Item Number

SKU	GTIN
MAB10050	04053252616594

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