Skip to Content
Merck

Key Documents

View All Documentation

MAB1919

Sigma-Aldrich

Anti-Fibrillin Antibody, clone 11C1.3

clone 11C1.3, Chemicon®, from mouse

Synonym(s):

Anti-ACMICD, Anti-FBN, Anti-GPHYSD2, Anti-MASS, Anti-MFLS, Anti-MFS1, Anti-OCTD, Anti-SGS, Anti-SSKS, Anti-WMS, Anti-WMS2

Sign Into View Organizational & Contract Pricing

Select a Size

All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

11C1.3, monoclonal

species reactivity

bovine, pig, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_000138.3

UniProt accession no.

P35555

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... FBN1(2200)

Immunogen

Bovine zonular fibrils

Application

Anti-Fibrillin Antibody, clone 11C1.3 is an antibody against Fibrillin for use in ELISA, IF, IP, WB, IH(P).
Immunoblot: antibody reacts with 350,000 Da protein released from bovine aortic smooth muscle cells, which is identical to that of fibrillin.

Immunohistochemistry: fresh frozen tissue: 1:200-1:500. Paraffin sections reactive after microwave citrate buffer antigen retrieval.

Immunoprecipitation: 5 microliters of antibody diluted in no more than 400 microliters of concentrated supernatants from bovine smooth muscle cells. We recommend either an anti-mouse IgG bead or a rabbit anti-mouse capture antibody followed by protein A.

ELISA

Optimal dilutions must be determined by the end user.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Biochem/physiol Actions

Bovine zonular fibrils. Reacts well with human elastin microfibrils and can be used to investigate the presence and organization of these fibrils either in Marfan patients or in fibroblasts obtained from these patients.

Physical form

Format: Purified
Liquid

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.
Kutz, WE; Wang, LW; Bader, HL; Majors, AK; Iwata, K; Traboulsi, EI; Sakai, LY; Keene, DR; Apte, SS
The Journal of Biological Chemistry null
A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis.
Taniguchi, et al.
Scientific Reports, 13, 4900-4900 (2023)
Hannah L Bader et al.
Matrix biology : journal of the International Society for Matrix Biology, 31(7-8), 398-411 (2012-09-27)
ADAMTS-like proteins are related to ADAMTS metalloproteases by their similarity to ADAMTS ancillary domains. Here, we have characterized ADAMTSL5, a novel member of the superfamily with a unique modular organization that includes a single C-terminal netrin-like (NTR) module. Alternative splicing
F Wang et al.
The British journal of dermatology, 173(6), 1420-1430 (2015-07-17)
Striae gravidarum (SG), or 'stretch marks' of pregnancy, begin as erythematous streaks, and mature over months to years to become permanent scar-like bands that may be hypopigmented, atrophic and lax. To investigate early molecular alterations that may promote laxity of
Mohamed A Sideek et al.
Matrix biology : journal of the International Society for Matrix Biology, 34, 114-123 (2013-10-24)
Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) is a protein of ill-defined function associated with elastic fibers during elastinogenesis. Although LTBP-2 binds fibrillin-1, fibulin-5, and heparin/heparan sulfate, molecules critical for normal elastic fiber assembly, it does not interact directly with
View All Related Papers

Global Trade Item Number

SKUGTIN
MAB191904053252267048

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service