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MAB1974

Anti-Integrin beta 3 (ITGB3/CD61) Antibody

CHEMICON®, mouse monoclonal, BB10

Synonym(s):

CD61

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
BB10, monoclonal
Species reactivity:
human
Application:
ICC, IHC, WB
Citations:
7
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Product Name

Anti-Integrin β3 Antibody, clone BB10, clone BB10, Chemicon®, from mouse

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BB10, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

isotype

IgG1

suitability

not suitable for immunohistochemistry (Paraffin)

NCBI accession no.

NM_000212.2

UniProt accession no.

P05106

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB3(3690)

Immunogen

Partially purified platelet glycoprotein IIb/lIIa complex.

Application

Anti-Integrin β3 Antibody, clone BB10 is an antibody against Integrin β3 for use in WB, IC, IH.
Immunoblotting: 1:1000 (Ylanne et al., 1988, 1990). The antibody is most effective when used against non-reduced samples.

immunohistochemistry (indirect immunofluorescence)1:200 - 1:400. (Ylanne et al., 1988).

Does not work on paraffin embedded sections.

Final working dilutions must be determined by end user.

Biochem/physiol Actions

Reacts with the beta-3 subunit of the integrin family, including GPIIIa of platelets. Recognized an extracellular epitope of beta-3.

Physical form

Format: Purified
Purified immunoglobulin. In PBS with 1% BSA and 0.1% sodium azide.

Preparation Note

Maintain between 2 and 8°C up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gwendolyn F Elphick et al.
Blood, 113(17), 4078-4085 (2009-02-27)
Integrin-mediated cell migration is central to many biologic and pathologic processes. During inflammation, tissue injury results from excessive infiltration and sequestration of activated leukocytes. Recombinant human activated protein C (rhAPC) has been shown to protect patients with severe sepsis, although
D Seger et al.
The Journal of biological chemistry, 276(20), 16998-17006 (2001-03-30)
Phosphorylation of vitronectin (Vn) by casein kinase II was previously shown to occur at Thr50 and Thr57 and to augment a major physiological function of vitronectin-cell adhesion and spreading. Here we show that this phosphorylation increases cell adhesion via the
M A Scragg et al.
Infection and immunity, 67(4), 1837-1843 (1999-03-20)
Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In this study we examined the effects of Porphyromonas gingivalis proteases on human gingival
View All Related Papers

Global Trade Item Number

SKUGTIN
MAB197404053252265020