MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

Name: Anti-Fibrillin (Pan) Antibody, clone 689
Brand: MM

clone 689, from mouse

Synonym(s):

EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Fibrillin (Pan) Antibody, clone 689, clone 689, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

689, monoclonal

species reactivity

mouse

species reactivity (predicted by homology)

chicken (based on 100% sequence homology), human (based on 100% sequence homology)

technique(s)

ELISA: suitable
immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

NP_115823

UniProt accession no.

Q75N90

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... EFEMP1(2202)

Analysis Note

Control
Mouse skin tissue

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

Application

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

Biochem/physiol Actions

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

General description

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

~ 350 kDa calculated

Immunogen

Recombinant protein corresponding to human Fibrillin 3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transient expression of Wnt5a elicits ocular features of pseudoexfoliation syndrome in mice.

Yong Yuan et al.

PloS one, 14(3), e0212569-e0212569 (2019-03-07)

Pseudoexfoliation (PEX) syndrome is an age-related systemic disease with ocular manifestations. The development of animal models is critical in order to elucidate the cause of the disease and to test potential treatment regimens. The purpose of this study is to

Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.

Tomoko Matsuzaki et al.

Journal of cellular physiology, 236(3), 1980-1995 (2020-07-31)

Fibrillins (FBNs) form mesh-like structures of microfibrils in various elastic tissues. RECK and FBN1 are co-expressed in many human tissues, suggesting a functional relationship. We found that dermal FBN1 fibers show atypical morphology in mice with reduced RECK expression (RECK-Hypo

Global Trade Item Number

SKU	GTIN
MAB2641	04053252629112

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