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Merck

MAB3301

Anti-TIMP-1 Antibody, clone 147-6D11

clone 147-6D11, Chemicon®, from mouse

Synonym(s):

Tissue Inhibitor of Metalloproteinase-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-TIMP-1 Antibody, clone 147-6D11, clone 147-6D11, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

147-6D11, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_003254.2

UniProt accession no.

P01033

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TIMP1(7076)

Application

Immunoblotting: Suggested Dilution 1μg/mL

Immunohistochemistry on paraffin-embedded tissue sections using PLP fixation; not tested on traditional formalin fixed tissues. Antigen retrieval is HIER methods

ElA
This Anti-TIMP-1 Antibody, clone 147-6D11 is validated for use in ELISA, WB, IH(P) for the detection of TIMP-1.

Biochem/physiol Actions

The antibody specifically reacts with human TIMP-1. This is a purified mouse monoclonal antibody to recombinant human tissue inhibitor of metalloproteinases-1 (recombinant TIMP-1).

SPECIES REACTIVITY:

Does not cross-react with mouse and rat TIMP-1.

Immunogen

Mouse Mac-1

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: MAB1338

Physical form

Format: Purified

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marcia Riboldi et al.
Reproduction (Cambridge, England), 160(5), 673-684 (2020-10-17)
During embryo implantation, endometrial angiogenesis is regulated by signals originating from the endometrium itself and the developing embryo. It has been suggested that hCG may play a pro-angiogenic role; therefore, we sought to understand its regulatory role in blood vessel
A Tapia-Pizarro et al.
Human reproduction (Oxford, England), 28(8), 2215-2227 (2013-05-23)
Are secreted extracellular matrix (ECM) remodelling elements, relevant to embryo implantation and placentation, modified by hCG in endometrial stromal cells (ESCs)? hCG decreases tissue inhibitor of metalloproteinase 1 (TIMP-1) secretion in ESCs, thereby facilitating extravillous trophoblast invasion in vitro. Successful
Philipp Christian Seppelt et al.
PloS one, 11(2), e0148012-e0148012 (2016-02-04)
Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vascular complications of Marfan syndrome have the biggest impact on life expectancy. The aorta of Marfan patients reveals degradation of elastin layers caused by increased proteolytic activity of

Global Trade Item Number

SKUGTIN
MAB330104053252399084

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