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Merck

MAB356

Anti-Substance P Antibody, pain, clone NC1

culture supernatant, clone NC1, Chemicon®

Synonym(s):

Anti-Hs.2563, Anti-NK2, Anti-NKNA, Anti-NPK, Anti-TAC2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Substance P Antibody, pain, clone NC1, culture supernatant, clone NC1, Chemicon®

biological source

rat

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

NC1, monoclonal

species reactivity

human

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG2a

NCBI accession no.

NM_003182.1
NM_013996.1
NM_013997.1
NM_013998.1

UniProt accession no.

P20366

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TAC1(6863)

Application

1:100 - 1:200 by immunohistochemistry on human brain.

Optimal working dilutions must be determined by end user.
Detect Substance P using this Anti-Substance P Antibody, pain, clone NC1 validated for use in IH.

Biochem/physiol Actions

Reacts with COOH-terminal end of Substance P. No cross-reactivity to Leu- or Met- enkephalin, somatostatin or beta-endorphin. Eledoisin 5%.

Immunogen

Substance P conjugated to BSA.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Lyophilized Supernatant, preservative free.

Preparation Note

Lyophilized antibody can be kept at 2-8°C for up to 3 months and should be kept at -20°C for long term storage. Reconstitute with 100μL sterile DI water. Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
Ding, S; Chi, MM; Scull, BP; Rigby, R; Schwerbrock, NM; Magness, S; Jobin, C; Lund, PK
Testing null
Liang Han et al.
Nature neuroscience, 21(3), 324-328 (2018-02-07)
Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction
Tibor Z Veres et al.
American journal of respiratory cell and molecular biology, 37(5), 553-561 (2007-06-30)
Neuroimmune interactions play a critical role in the pathogenesis of asthma. Symptoms like wheezing and cough have been attributed to neural dysregulation, whereas sensitization and the induction of allergic inflammation have been linked with the activity of dendritic cells. Neuropeptides
Andrew P Ray et al.
Pharmacology, biochemistry, and behavior, 94(1), 211-218 (2009-08-25)
Research on the mechanisms of emesis has implicated multiple neurotransmitters via both central (dorsal vagal complex) and peripheral (enteric neurons and enterochromaffin cells) anatomical substrates. Taking advantage of advances in receptor-specific agonists, and utilizing Fos expression as a functional activity
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Zimmer, A; Zimmer, AM; Baffi, J; Usdin, T; Reynolds, K; Konig, M; Palkovits, M; Mezey, E
Proceedings of the National Academy of Sciences of the USA null
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Global Trade Item Number

SKUGTIN
MAB35604053252317958

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