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Merck

MAB3731

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

clone 6AT1877, Chemicon®, from mouse

Synonym(s):

c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877, clone 6AT1877, Chemicon®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6AT1877, monoclonal

species reactivity

human, mouse

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable

isotype

IgG1

NCBI accession no.

NM_000245.2

UniProt accession no.

P08581

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr1234/pTyr1235)

Quality Level

100

Gene Information

human ... MET(4233)
mouse ... Met(17295)

Application

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.
ELISA (direct): 1:1,000

Optimal working dilutions must be determined by the end user.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Biochem/physiol Actions

Reacts with Met/HGFR (Hepatocyte growth factor receptor) only when phosphorylated at Tyr1234 and Tyr1235. The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for Met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Epitope: phospho-specific (Tyr1234/1235)
Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/1235 of human Met.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
MAB373104053252617270

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