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MAB3878

Anti-MyoD1 Antibody

Name: Anti-MyoD1 Antibody
Brand: MM

clone 5.2F, Chemicon^®, from mouse

Synonym(s):

Anti-MYF3, Anti-MYOD, Anti-MYODRIF, Anti-PUM, Anti-bHLHc1

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5.2F, monoclonal

species reactivity

rat, mouse, chicken, human

manufacturer/tradename

Chemicon^®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_002478.4

UniProt accession no.

P15172

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MYOD1(4654)

General description

~ 45 kDa

Immunogen

Recombinant protein from mouse MyoD1.

Application

Anti-MyoD1 Antibody is a high quality Mouse Monoclonal Antibody for the detection of MyoD1 & has been validated in ICC, IHC, IP & WB.

Western blot: 1 μg/mL. Reacts with the ~45 kD protein.

Immunohistochemistry on frozen and formalin-fixed, paraffin embedded tissue: 2-4 μg/mL.

Immunocytochemistry

Immunoprecipitation: 2 μg/mg of protein lysate

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Recognizes MyoD1. The epitope is localized to amino acids 3-56 in the N-terminus of mouse MyoD1 protein.

Physical form

Format: Purified

Analysis Note

Control
Fetal Muscle, Rhabdomyosarcoma

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.

Kohsaka, S; Shukla, N; Ameur, N; Ito, T; Ng, CK; Wang, L; Lim, D; Marchetti, A; Viale et al.

Nature Genetics null

p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program.

Mark A Gillespie et al.

The Journal of cell biology, 187(7), 991-1005 (2009-12-23)

The mitogen-activated protein kinase p38-gamma is highly expressed in skeletal muscle and is associated with the dystrophin glycoprotein complex; however, its function remains unclear. After induced damage, muscle in mice lacking p38-gamma generated significantly fewer myofibers than wild-type muscle. Notably

Premature senescence in primary muscle cultures of myotonic dystrophy type 2 is not associated with p16 induction.

L V Renna et al.

European journal of histochemistry : EJH, 58(4), 2444-2444 (2015-01-13)

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are multisystemic disorders linked to two different genetic loci and characterized by several features including myotonia, muscle weakness and atrophy, cardiac dysfunctions, cataracts and insulin-resistance. In both forms, expanded nucleotide sequences

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.

Francesca Megiorni et al.

Journal of hematology & oncology, 10(1), 161-161 (2017-10-08)

EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR

In situ mechanotransduction via vinculin regulates stem cell differentiation.

Holle, AW; Tang, X; Vijayraghavan, D; Vincent, LG; Fuhrmann, A; Choi, YS; del Alamo, JC; Engler, AJ

Stem Cells null

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Global Trade Item Number

SKU	GTIN
MAB3878	04053252725661

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