MAB4132

Anti-BRCA1 Antibody, clone BR64

Name: Anti-BRCA1 Antibody, clone BR64
Brand: MM

clone BR64, Chemicon^®, from mouse

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-BRCA1 Antibody, clone BR64, clone BR64, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

BR64, monoclonal

species reactivity

human, mouse

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_007294.2
NM_007295.2
NM_007296.2
NM_007297.2
NM_007298.2
NM_007299.2
NM_007300.2
NM_007302.2
NM_007303.2
NM_007304.2
NM_007305.2

UniProt accession no.

P38398

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Analysis Note

Tested

Application

Anti-BRCA1 Antibody, clone BR64 is a high quality Mouse Monoclonal Antibody for the detection of BRCA1 & has been validated in IP & WB.

Immunoprecipitation

Western blot

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

The breast cancer susceptibility gene, BRCA1*, is located on chromosome 17 (at q21), and is mutated in the majority of heritable breast cancers. The mutations within the coding region occur throughout the gene with little apparent clustering. The majority of BRCA1 mutations result in shortened BRCA1 gene products, creating a need for an amino-terminal marker. Antibody MAB4132 recognizes both the full-length and mutated (shortened) forms of BRCA1 in breast cancer cell lines. It also recognizes over-expressed protein in transiently transfected Cos cells. A single cross-reacting protein of approximately 27 kDa is also seen upon immunoprecipitation. No other cross-reacting proteins are detected.

BRAC1 is 220kDa.

*BRCA1 is covered under U.S. patents 5,747,282, 5,753,441 and 6,162,897.

Immunogen

Purified polypeptide representing a 100-amino acid segment of the amino terminus of the BRCA1 gene product.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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BRCA1 Antibodies Matter.

Jing Yang et al.

International journal of biological sciences, 17(12), 3239-3254 (2021-08-24)

Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling

Global Trade Item Number

SKU	GTIN
MAB4132	04053252726774
MAB4132-25UG	04054839350382

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