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MAB4369

Anti-SRF [Serum Response Factor] Antibody, clone 1E1

Name: Anti-SRF [Serum Response Factor] Antibody, clone 1E1
Brand: MM

clone 1E1, from mouse

Synonym(s):

serum response factor (c-fos serum response element-binding transcription factor)

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

1E1, monoclonal

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
western blot: suitable

input

sample type neural stem cell(s)
sample type mesenchymal stem cell(s)

isotype

IgG1κ

UniProt accession no.

P11831

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ELK3(2004)

General description

Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE), and is essential for embryonic development of the mesoderm, as well as for the maintenance of adult muscle cells and neurons. As this protein is involved in the downstream regulation of many immediate-early genes, it participates in a variety of cell functions, including cell cycle, apoptosis, cell growth, and cell differentiation. SRF is most commonly activated by serum, LPA, LPS, TPA, growth factors, including TNFalpha, as well as antioxidants and UV light.

~52 kDa

Immunogen

Synthetic human SRF peptide, a.a. 406-508.

Application

Detect SRF [Serum Response Factor] using this Anti-SRF [Serum Response Factor] Antibody, clone 1E1 validated for use in WB & IC.

Immunocytochemistry: Recommended working dilution is 1:500.

Research Category
Stem Cell Research

Research Sub Category
Mesenchymal Stem Cells

Neural Stem Cells

Biochem/physiol Actions

A weak interaction with mouse has also been observed. Reactivity with other species has not been tested.

This monoclonal antibody recognizes SRF.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.

Analysis Note

(Based upon representative data from a previous lot).

Western Blotting: Recommended working dilution is 0.5 µg/mL.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Resveratrol Enhances Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells through Inhibiting Canonical WNT Signal Pathway and Enhancing Serum Response Factor-miR-1 Axis.

Hui Liu et al.

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Resveratrol (trans-3,5,4'-trihydroxystilbene) (RSV) is a natural polyphenol with protective effects over cardiac tissues and can affect cell survival and differentiation in cardiac stem cells transplantation. However, whether this agent can affect cardiomyocytes (CMs) differentiation of induced pluripotent stem cells (iPSCs)

A human Dravet syndrome model from patient induced pluripotent stem cells.

Norimichi Higurashi et al.

Molecular brain, 6, 19-19 (2013-05-04)

Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the α-subunit of the voltage-gated sodium channel Na(v)1.1. Disease modeling using patient-derived induced pluripotent stem cells (iPSCs) can

Global Trade Item Number

SKU	GTIN
MAB4369	04053252727535

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