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Merck

MAB4407

Sigma-Aldrich

Anti-HESCA-1 Antibody, clone 051007-4A5

clone 051007-4A5, Chemicon®, from mouse

Synonym(s):

Human Embryonic Stem Cell Antigen-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

051007-4A5, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

input

sample type: human embryonic stem cell(s)
sample type induced pluripotent stem cell(s)

isotype

IgMκ

shipped in

wet ice

target post-translational modification

unmodified

Related Categories

General description

200 kDa
The evolution of our understanding of pluripotent and adult stem cell biology requires specific research tools to permit the characterization, isolation, and expansion of stem cells. HESCA-1, developed in collaboration with Abeome Corporation, is the first in a series of novel, human embyronic stem cell antibodies produced to provide scientists with those needed tools. This novel monoclonal antibody recognizes a newly discovered 200 kDa cell surface protein that has been shown to be expressed in pluripotent human embryonic stem cell (hESC) populations.

Immunogen

BG01v hES cell line

Application

Detect HESCA-1 (Human Embryonic Stem Cell Antigen-1) using this Anti-HESCA-1 Antibody, clone 051007-4A5 validated for use in IC, IH, IF, FC.
Research Category
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation

Biochem/physiol Actions

Reactivity to other species has not been determined.
This antibody is positive by immunofluorescence against H1, BG-01, BG01v, and BF02 human embryonic stem (hES) cell lines; however, it is unreactive for differentiated stem cells in teratomas and common feeder lines such as MEF, D-551, and Hs27. Reactivity with other hES lines has not yet been determined.

Physical form

Format: Purified
Liquid in 0.02M PBS, 0.25 NaCl, pH 7.6 with 0.1% Sodium Azide

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Related Content

Human Stem Cell Systems

As the focus of stem cell research undergoes a transition from animal to human models, researchers are in critical need of validated products to support the isolation, maintenance, differentiation, and characterization of human stem cells. While many reagents designed for rodent systems can be applied to human stem cell studies, they are not truly optimized for robust human stem cell culture or analysis. This is why human stem cell researchers have always trusted EMD Millipore, the first provider of commercially available human embryonic stem cells and human neural stem cell lines, to accelerate their research. All of our human stem cell systems are extensively tested in defined media culture, and differentiated progeny are comprehensively characterized with highly validated antibodies and detection reagents.

HESCA-1 (HUMAN EMBRYONIC STEM CELL ANTIGEN-1)
HESCA-1 and HESCA-2: Novel Antibodies for the Identification of Human Embryonic Stem Cells
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

Global Trade Item Number

SKUGTIN
MAB440704053252398414

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