Key Documents
MAB5204
Anti-Agrin Antibody
Chemicon®, from mouse
Synonym(s):
Anti-AGRIN, Anti-CMSPPD
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
monoclonal
species reactivity
mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... AGRN(375790)
Immunogen
Recombinant rat agrin (C-terminal construct)
Application
Anti-Agrin Antibody is an antibody against Agrin for use in WB & IC.
Immunocytochemistry: 10 μg/mL
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Growth Cones & Axon Guidance
Synapse & Synaptic Biology
Growth Cones & Axon Guidance
Synapse & Synaptic Biology
Biochem/physiol Actions
MAB5204 recognizes rat and mouse agrin. The epitope has been mapped near the splicing site Z. Binding of this antibody to agrin causes marked reduction in nAChR clusters.
Physical form
Format: Purified
Purified immunoglobulin. Liquid in PBS containing 50% glycerol and 0.09% sodium azide.
Preparation Note
Maintain lyophilized at material -20°C or below for up to 12 months. After reconstitution maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Nandor Nagy et al.
Development (Cambridge, England), 145(9) (2018-04-22)
The enteric nervous system (ENS) arises from neural crest cells that migrate, proliferate, and differentiate into enteric neurons and glia within the intestinal wall. Many extracellular matrix (ECM) components are present in the embryonic gut, but their role in regulating
The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.
Hoover, CL; Hilgenberg, LG; Smith, MA
The Journal of cell biology null
Paul J Thomas et al.
The American journal of pathology, 186(9), 2429-2448 (2016-08-27)
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Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19348-19353 (2013-11-06)
The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is caused by deficiency of SMN (survival motor neuron), a ubiquitous and indispensable protein essential for biogenesis of snRNPs, key components of pre-mRNA processing. However, SMA's hallmark MN pathology, including
Silvia Scaricamazza et al.
British journal of pharmacology, 179(8), 1732-1752 (2021-11-17)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor neuron disease, increasing evidence indicates
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB5204 | 04053252464904 |
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