MAB5354

Anti-Amyloid Precursor Protein (APP) Antibody

Name: Anti-Amyloid Precursor Protein (APP) Antibody
Brand: MM

CHEMICON^®, mouse monoclonal, 4.1

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Product Name

Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1, clone 4.1, Chemicon^®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.1, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000484.2
NM_201413.1
NM_201414.1

UniProt accession no.

P05067

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... APP(351)

Application

Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1 detects level of Amyloid β Precursor Protein & has been published & validated for use in ELISA, WB, IH.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western blot: 2-5 μg/mL using ECL on human brain or platelets. Recognizes a protein of 100-120 kDa.

Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.

ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Amyloid-beta Precursor Protein, KPI (Kunitz protease inhibitor) domain. The antibody reacts with both native and recombinant protein. The antibody has been shown to partially inhibit protease inhibitory properties.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Epitope: KPI domain

Purified recombinant KPI domain of Amyloid-beta precursor protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Purified immunoglobulin. Liquid in 20 mM Sodium phosphate buffer with 150 mM NaCl.

Preparation Note

Maintain at 2-8°C in undiluted aliquots for up to 6 months of date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex.

Jochen Winterer et al.

Cell reports, 19(6), 1110-1116 (2017-05-13)

The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-? production.

Bordji, K; Becerril-Ortega, J; Nicole, O; Buisson, A

The Journal of Neuroscience null

Global Trade Item Number

SKU	GTIN
MAB5354	04053252463693

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