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Merck

MAB5384A4

Anti-NG2 Antibody, clone 132.39, Alexa Fluor™488 Conjugate

clone 132.39, from mouse, ALEXA FLUOR™ 488

Synonym(s):

Chondroitin sulfate proteoglycan 4, Chondroitin sulfate proteoglycan NG2, HSN tumor-specific antigen

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-NG2 Antibody, clone 132.39, Alexa Fluor™488 Conjugate, clone 132.39, from mouse, ALEXA FLUOR™ 488

biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

132.39, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

mouse, human

technique(s)

immunocytochemistry: suitable

isotype

IgG1

NCBI accession no.

NP_112284

UniProt accession no.

Q00657

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CSPG4(1464)
mouse ... Cspg4(121021)
rat ... Cspg4(81651)

Application

Research Sub Category
Developmental Neuroscience
Anti-NG2 Antibody, clone 132.39, Alexa Fluor™488 Conjugate detects level of NG2 & has been published & validated for use in ICC.
Research Category
Neuroscience

Analysis Note

Control
Rat oligodendrocyte precursor cells
Evaluated by Immunocytochemistry in rat oligodendrocyte precursor cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected NG2 in rat oligodendrocyte precursor cells. Performed without Triton.

Biochem/physiol Actions

This antibody recognizes the native, recombinant, and protein from cells which express NG2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

NG2 is a high molecular weight, integral membrane chondroitin sulfate proteoglycan. It is found on the surfaces of an unusual class of glial cells within the developing and mature central nervous system that have the properties of oligodendrocyte precursor cells (i.e., O-2A progenitor cells). NG2 is also found on the surfaces of chondroblasts, proliferating capillary endothelial cells, some human melanoma cell lines, and on leukemic blasts in childhood acute lymphoblastic leukemia. The NG2 proteoglycan is likely to play a role in regulation of cell motility, axon outgrowth and the cellular responses to platelet-derived growth factor.
The unconjugated parent antibody (Cat. No. MAB5384) has an observed molecular weight at ~280 kDa

Immunogen

Cell line expressing a truncated form of NG2

Physical form

Protein G Purified
Purified mouse monoclonal IgG1 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Preparation Note

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Annika Andersson-Sjöland et al.
Laboratory investigation; a journal of technical methods and pathology, 96(2), 206-217 (2015-09-15)
Pulmonary fibrosis is a grave diagnosis with insidious progression, generally considered as a consequence of aberrant epithelial wound healing and excessive scarring. This process is commonly modeled in animals by local bleomycin administration, resulting in peribronchial inflammation and subsequent fibrosis.
Yitao Zhu et al.
Nature (2024-08-31)
Human mutations in neuropeptide Y (NPY) have been linked to high body mass index but not altered dietary patterns1. Here we uncover the mechanism by which NPY in sympathetic neurons2,3 protects from obesity. Imaging of cleared mouse brown and white adipose
Kristina Rydell-Törmänen et al.
Scientific reports, 4, 6383-6383 (2014-09-19)
The ECM exerts great effects on cells, and changed composition may therefore have profound impact. Small leucine-rich proteoglycans, e.g. fibromodulin, are essential in collagen assembly. Our aim was to investigate the role of fibromodulin in healthy and fibrotic lung parenchyma

Global Trade Item Number

SKUGTIN
MAB5384A404053252647758

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