MAB5466

Anti-Bestrophin Antibody

Name: Anti-Bestrophin Antibody
Brand: MM

Chemicon^®, from mouse

Synonym(s):

Anti-Anti-ARB, Anti-Anti-BEST, Anti-Anti-BMD, Anti-Anti-Best1V1Delta2, Anti-Anti-RP50, Anti-Anti-TU15B, Anti-Anti-VMD2

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All Photos(2)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Bestrophin Antibody, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

monoclonal

species reactivity

monkey, pig, mouse, bovine, human

manufacturer/tradename

Chemicon^®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_004183.2

UniProt accession no.

O76090

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BEST1(7439)

Application

Detect Bestrophin using this Anti-Bestrophin Antibody validated for use in WB, IH.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western blot: 5 μg/mL of this antibody detected Bestrophin in bovine retina cell lysate.

Immunohistochemistry (Paraffin) Analysis: A 1:20 dilution from a representative lot detected Bestrophin in mouse retina tissue sections.

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Reacts with bestrophin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Recombinant human bestrophin protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.08% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium.

??lvarez-Barrios, et al.

Frontiers in nutrition, 10, 1124987-1124987 (2023)

Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration.

Sandra Petrus-Reurer et al.

Stem cells translational medicine, 9(8), 936-953 (2020-04-23)

As pluripotent stem cell (PSC)-based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies are in development, and treatment for

Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.

Teisha J Rowland et al.

Journal of tissue engineering and regenerative medicine, 7(8), 642-653 (2012-04-20)

A potential application of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is the generation of retinal pigmented epithelium (RPE) to treat age-related macular degeneration (AMD), a common but incurable retinal disease. RPE cells derived from hESCs

Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells.

Alvaro Plaza Reyes et al.

Nature communications, 11(1), 1609-1609 (2020-04-02)

In vitro differentiation of human pluripotent stem cells into functional retinal pigment epithelial (RPE) cells provides a potentially unlimited source for cell based reparative therapy of age-related macular degeneration. Although the inherent pigmentation of the RPE cells have been useful

Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.

Divya Sinha et al.

American journal of human genetics, 107(2), 278-292 (2020-07-25)

Dominantly inherited disorders are not typically considered to be therapeutic candidates for gene augmentation. Here, we utilized induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) to test the potential of gene augmentation to treat Best disease, a dominant macular dystrophy

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Global Trade Item Number

SKU	GTIN
MAB5466	04053252400179

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