MAB5512
Anti-Parkin Antibody, clone PRK8
ascites fluid, clone PRK8, Chemicon®
Synonym(s):
Anti-AR-JP, Anti-LPRS2, Anti-PARK2, Anti-PDJ
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PRK8, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PARK2(5071)
Immunogen
Recombinant human parkin.
Application
Anti-Parkin Antibody, clone PRK8 is an antibody against Parkin for use in IP, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot. The antibody detects ~50 and ~44 kDa bands in mouse brain extracts. In human brain extracts the antibody reacts with ~50 and ~46 kDa. Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Parkin. The epitope recognizes by the monoclonal is between animo acids 399-465 of human parkin. The antibody shows no cross-reactivity with protein in extracts from parkin null mice.
Physical form
Ascites fluid. Liquid. Contains no preservative.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Related Content
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.
Duplan, E; Sevalle, J; Viotti, J; Goiran, T; Bauer, C; Renbaum, P; Levy-Lahad, E; Gautier et al.
Journal of Molecular Cell Biology null
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.
Huynh, DP; Nguyen, DT; Pulst-Korenberg, JB; Brice, A; Pulst, SM
Experimental neurology null
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
da Costa, CA; Sunyach, C; Giaime, E; West, A; Corti, O; Brice, A; Safe, S; Abou-Sleiman et al.
Nature Cell Biology null