MABC147

Anti-TRAIL/CD253 Antibody, clone 6D12.2

Name: Anti-TRAIL/CD253 Antibody, clone 6D12.2
Brand: MM

clone 6D12.2, from mouse

Synonym(s):

Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-TRAIL/CD253 Antibody, clone 6D12.2, clone 6D12.2, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6D12.2, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

NP_001177871

UniProt accession no.

P50591

shipped in

wet ice

target post-translational modification

unmodified

Analysis Note

Evaluated by Flow Cytometry in HeLa cells, which were treated with a proinflammatory stimulus.

Flow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 HeLa cells, which were treated with a proinflammatory stimulus.

Application

Anti-TRAIL/CD253 Antibody, clone 6D12.2 is an antibody against TRAIL/CD253 for use in flow cytometry & IHC.

Flow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 human PBMC, which were treated with a proinflammatory stimulus.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAIL/CD253 in human prostate cancer sections. (Note: This antibody detects TRAIL/CD253 in cancer tissues and not in normal tissues.).

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

33 kDa calculated

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

Immunogen

GST-tagged recombinant protein corresponding to human TRAIL/CD253.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKU	GTIN
MABC147	04053252955136

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