MABC536
Anti-Vasohibin-2, clone 5E3 Antibody
clone 5E3, 1 mg/mL, from mouse
Synonym(s):
Vasohibin-2, Vasohibin-like protein
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5E3, monoclonal
Application:
IHC, WB
Citations:
3
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5E3, monoclonal
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... VASH2(79805)
General description
Vasohibin-2, also known as Vasohibin-like protein, and encoded by the gene VASH2/VASHL, is a developmental regulator protein of angiogenesis induced by VEGF and present in various embryonic organs at six to 12 twelve weeks of development in humans. Vasohibin-2 acts as an angiogenesis inhibitor and is thought to help regulate organ vessel formation and maturation. In cancer, Vascohibin-2 appears to act to promote angiogenesis and is expressed in many cancers. In cancer cells, there are two isoforms. VASH2 (with 355 amino acid residues) is located in the cytoplasm while VASH2 (with 311 amino acid residues) is located in the nucleus. The former was found to be a relatively low abundance protein.
~40 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to human Vasohibin 2.
Application
Anti-Vasohibin-2 antibody, clone 5E3 is an antibody against Vasohibin-2 for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Vasohibin 2 in human placenta tissue.
Immunohistochemistry Analysis: A representative lot detected Vasohibin 2 in human and mouse embryonic lung tissue (Shibuya, T., et al. (2006). American Heart Association. 26:1051-1057).
Immunohistochemistry Analysis: A representative lot detected Vasohibin 2 in human and mouse embryonic lung tissue (Shibuya, T., et al. (2006). American Heart Association. 26:1051-1057).
Physical form
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives .
Analysis Note
Evaluated by Western Blotting in HUVEC cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Vasohibin 2 in 10 µg of HUVEC cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Vasohibin 2 in 10 µg of HUVEC cell lysate.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Trevor J Mathias et al.
Cancers, 14(7) (2022-04-13)
Post-translational modifications (PTMs) of the microtubule network impart differential functions across normal cell types and their cancerous counterparts. The removal of the C-terminal tyrosine of α-tubulin (deTyr-Tub) as performed by the tubulin carboxypeptidase (TCP) is of particular interest in breast
Siem van der Laan et al.
Cell reports, 29(12), 4159-4171 (2019-12-19)
The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABC536 | 04053252975752 |