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MABC615

Anti-TNFα Receptor Antibody, clone 13F9.1

Name: Anti-TNFα Receptor Antibody, clone 13F9.1
Brand: MM

clone 13F9.1, from mouse

Synonym(s):

Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis f

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All Photos(3)

About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

13F9.1, monoclonal

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001056

UniProt accession no.

P19438

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TNF(7124)

General description

Tumor necrosis factor receptor superfamily member 1A (UniProt P19438; also known as CD120a, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor-alpha receptor, Tumor necrosis factor receptor type 1) is encoded by the TNFRSF1A (also known as FPF, MS5, TNFAR, TNFAR55, TNFAR60, TNFR1) gene (Gene ID 7132) in human. It functions as a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. Upon activation, TNFalpha receptor mediates apoptotic, anti-viral, and other cellular signaling events. Binding of TNF-alpha to the extracellular domain of TNF receptor leads to homotrimerization. Proteolytic cleavage results in the relese of Tumor necrosis factor-binding protein 1 (TBP1). Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia.

~50/43 kDa observed. 50.5 kDa (isoform 1/FL-TNFR1 calculated), 38.7 kDa (isoform 2 calculated), 25.6 kDa (isoform 4/Delta6-TNFR1 calculated), 24.2 kDa (isoform 5 calculated).

Immunogen

GST-tagged recombinant protein corresponding to the extracellular domain of human TNFα Receptor.

Application

Anti-TNF apha Receptor Antibody, clone 13F9.1 is a highly specific mouse monoclonal antibody, that targets TNFα Receptor & has been tested in Western Blotting, and Immunohistochemistry.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected TNFα Receptor in 10 µg of HepG2 and RAW264 cell lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TNFα Receptor in human colon tissue and human colon cancer cells.

Biochem/physiol Actions

Expected to react with spliced isoforms 1/FL-TNFR1, 2, 4/Delta6-TNFR1, and 5, but not isoform 3.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected TNFα Receptor in 10 µg of Jurkat cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TNFα in the Trigeminal Nociceptive System Is Critical for Temporomandibular Joint Pain.

Qian Bai et al.

Molecular neurobiology, 56(1), 278-291 (2018-04-27)

Previous studies have shown that tumor necrosis factor alpha (TNFα) is significantly increased in complete Freund's adjuvant (CFA)-treated temporomandibular joint (TMJ) tissues. However, it is unclear whether TNFα in the trigeminal nociceptive system contributes to the development of TMJ pain.

Global Trade Item Number

SKU	GTIN
MABC615	04055977171419

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