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Merck

MABE1033

Anti-SMARCB1 Antibody, clone 2C2

clone 2C2, from mouse

Synonym(s):

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, hSNF5, SMARCB1

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About This Item

eCl@ss:
32160702
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-SMARCB1 Antibody, clone 2C2, clone 2C2, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2C2, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001007469

UniProt accession no.

Q12824

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SMARCB1(6598)

Analysis Note

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SMARCB1 in 10 µg of HeLa cell lysate.

Application

Anti-SMARCB1 Antibody, clone 2C2 is an antibody against SMARCB1 for use in Western Blotting and Immunocytochemistry.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected SMARCB1 in 10 µg of HEK293 cell lysate.
Immunocytochemistry Analysis: A representative lot detected SMARCB1 in HeLa cells (Harada, A., et al. (2014). Mono. Antibodies in Immuno. and Immunotherapy. 33:49-51).
Western Blotting Analysis: A representative lot detected SMARCB1 in HeLa cells (Harada, A., et al. (2014). Mono. Antibodies in Immuno. and Immunotherapy. 33:49-51).

General description

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), also known as BRG1-associated factor 47 (BAF47) or Integrase interactor 1 protein or SNF5 homolog (hSNF5), and encoded by the gene name SMARCB1 or BAF47, is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein has also been shown to bind to and enhance the DNA joining activity of HIV-1 integrase. It has been found to be a tumor suppressor, and the loss of SMARCB1 has been associated with malignant rhabdoid tumors. Tumor cells of synovial sarcoma seem to have a post transcriptional regulatory mechanism for SMARCB1.
~ 45 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to human SMARCB1.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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