MABE145

Anti-Runx3 Antibody, clone R3-5G4

Name: Anti-Runx3 Antibody, clone R3-5G4
Brand: MM

clone R3-5G4, from mouse

Synonym(s):

Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Runx3 Antibody, clone R3-5G4, clone R3-5G4, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

R3-5G4, monoclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001026850

UniProt accession no.

Q13761

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RUNX3(864)

Analysis Note

Control
Daudi cell lysate.

Evaluated by Western Blot in Daudi cell lysate.

Western Blot Analysis: 0.25 mg/mL of this antibody detected Runx3 in 10 µg Daudi cell lysate.

Application

Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Runx3 in HCT116, SW620, and SW480 nuclear extracts. (Ito, K., et al. (2008). Cancer Cell. 14(3):226-237.)

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Use Anti-Runx3 Antibody, clone R3-5G4 (mouse monoclonal antibody) validated in WB, IP to detect Runx3 also known as Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, PEA2-alpha C, PEBP2-alpha C.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Runx3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5′-PYGPYGGT-3′ found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.

~44 kDa observed

Immunogen

Recombinant protein corresponding to human Runx3.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells.

Simon I Dreher et al.

Frontiers in cell and developmental biology, 8, 81-81 (2020-03-21)

Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal progenitor cell (MPC) chondrogenesis is considered as a valuable model to better understand hypertrophic development of chondrocytes. Transcription factors Runx2

Global Trade Item Number

SKU	GTIN
MABE145	04053252427169

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