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Merck

MABE270

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

clone 19E2.1, from mouse

Synonym(s):

Signal transducer and activator of transcription 6, IL-4 Stat

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
19E2.1, monoclonal
Species reactivity:
human, mouse
Application:
FACS, WB
Citations:
-

Key Documents

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biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

19E2.1, monoclonal

species reactivity

human, mouse

technique(s)

flow cytometry: suitable, western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001171549

UniProt accession no.

P42226

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr641)

Quality Level

100

Gene Information

human ... STAT6(6778)

Related Categories

General description

Signal transducer and activator of transcription 6 (STAT6) transduces signals from extracellular cytokines during adaptive immunity and has recently been found to be important in the innate immune response to viral infection. STAT6 is also involved in the attenuation of the Th1 and Th17 in the nephritogenic immune response. The consequence of STAT6 activity has been associated with the pathogenesis of autoimmune disease and has been found to be actively imported to the nucleus.
~165 kDa observed

Immunogen

Epitope: Phosphorylated (Tyr641)
KLH-conjugated linear peptide corresponding to human STAT6 phosphorylated at (Tyr641).

Application

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.
Flow Cytometry Analysis: 2 µg/mL from a representative lot detected STAT6 in human peripheral blood leukocytes.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Biochem/physiol Actions

This antibody recognizes STAT6 phosphorylated at (Tyr641).

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
NIH/3T3 cell lysates treated and untreated with PDGF
Evaluated by Western Blot in NIH/3T3 cell lysates treated and untreated with PDGF.

Western Blot Analysis: 0.5 µg/mL of this antibody detected STAT6 on 10 µg of PDGF untreated and treated NIH/3T3 cell lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Related Content

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JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

Global Trade Item Number

SKUGTIN
MABE27004053252686856

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