Key Documents
MABN1117
Anti-Pannexin 1, clone EPR5556, Rabbit Monoclonal Antibody
clone EPR5556, from rabbit
Synonym(s):
Pannexin-1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
unpurified
antibody product type
primary antibodies
clone
EPR5556, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PANX1(24145)
General description
Pannexin 1 (PANX1) belongs to the innexin family. Innexin family members are the structural components of gap junctions. Pannexin 1 and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that Pannexin 1 alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Immunogen
Synthetic peptide corresponding to human Pannexin 1.
Application
Produced in collaboration with Epitomics
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-Pannexin 1, clone EPR5556, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of Pannexin 1.
Physical form
Format: Unpurified
Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Analysis Note
Evaluated by Western Blotting in human fetal brain, SH-SY5Y, Caco-2, and NIH:OVACAR-3 lysates.
Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Pannexin 1 in human fetal brain, SH-SY5Y, Caco-2, and NIH:OVACAR-3 lysates.
Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Pannexin 1 in human fetal brain, SH-SY5Y, Caco-2, and NIH:OVACAR-3 lysates.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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