MABN1191

Anti-Parvalbumin Antibody, clone 4E9.2

Name: Anti-Parvalbumin Antibody, clone 4E9.2
Brand: MM

clone 4E9.2, from mouse

Synonym(s):

Parvalbumin alpha, Parvalbumin, PV

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

4E9.2, monoclonal

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_071944

UniProt accession no.

P02625

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PVALB(5816)
mouse ... Pvalb(19293)
rat ... Pvalb(25269)

General description

Parvalbumin alpha (UniProt P02625; also known as PV) is encoded by the Pvalb (also known as Pva) gene (Gene ID 25269) in rat species. Parvalbumin alpha is a small (a.a. 2-110; Met1 removed posttranslationally) calcium-binding protein. Parvalbumin alpha is composed almost entirely of two EF-hand domains (a.a. 39-74 & 78-110) and is structurally related to calmodulin and troponin C. Parvalbumin (PV) is present in GABAergic interneurons in the nervous system, especially the reticular thalamus. PV interneurons are a subset of inhibitory GABAergic neurons that control the excitability of post-synaptic pyramidal neurons. Dysfunction or loss of PV interneurons is implicated in cognitive deficits associated with a number of well known psychiatric disorders, including schizophrenia, Alzheimer’s disease, and depression.

~12 kDa observed. 11.93 kDa (human), 11.80 kDa (mouse), 11.79 kDa (rat) calculated (Met1 removed). Uncharacterized band(s) may appear in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of rat parvalbumin.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Parvalbumin in human kidney, rat kidney, and mouse cerebral cortex tissue sections.

This Anti-Parvalbumin Antibody, clone 4E9.2 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Parvalbumin.

Biochem/physiol Actions

Clone 4E9.2 detects an epitope conserved among human, mouse, and rat species.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected Parvalbumin in 10 µg of mouse brain tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice.

Sahithi Attaluri et al.

Frontiers in aging neuroscience, 15, 1200445-1200445 (2023-07-10)

Extracellular vesicles (EVs) released by human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) have robust antiinflammatory and neurogenic properties due to therapeutic miRNAs and proteins in their cargo. Hence, hiPSC-NSC-EVs are potentially an excellent biologic for treating neurodegenerative disorders

Global Trade Item Number

SKU	GTIN
MABN1191	04055977352993

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