MABN128

Anti-PITX3 Antibody, clone 12G4.1

Name: Anti-PITX3 Antibody, clone 12G4.1
Brand: MM

clone 12G4.1, from mouse

Synonym(s):

Pituitary homeobox 3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

12G4.1, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_005020

UniProt accession no.

O75364

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PITX3(5309)

General description

Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson′s disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.

~32 kDa observed. Uncharacterized band(s) may appear in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.

Application

Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)