Anti-α-Synuclein (SNCA) Antibody

Alpha-synuclein (UniProt: P37840; also known as Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP) is encoded by the SNCA (also known as NACP, PARK1) gene (Gene ID 6622) in human. Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of Parkinson′s disease brains. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. It may also be involved in the regulation of dopamine release and transport. It is also reported to reduce neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA gene is reported to result in aberrant polymerization into fibrils, which is associated with several neurodegenerative diseases (synucleinopathies). Mutations in SNCA gene are also known to Parkinson′s disease characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology of Parkinson s disease involves progressive loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in surviving neurons in various areas of the brain.

~15 kDa observed; 14.5 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

A recombinant fragment from the C-terminal region of human alpha synuclein.

Anti-alpha-Synuclein, clone 9C4, Cat. No. MABN1805, is a highly specific mouse monoclonal antibody, that targets alpha synuclein and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected alpha synuclein in human cerebellum, human cerebral cortex, and human bone marrow tissues.

Research Category
Neuroscience

Clone 9C4 detects alpha synuclein in human brain.

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in human fetal brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected alpha synuclein in 10 µg of human fetal brain tissue lysate.

Concentration: Please refer to lot specific datasheet.

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