MABN281

Anti-Numb Antibody, clone 6G10.1

Name: Anti-Numb Antibody, clone 6G10.1
Brand: MM

clone 6G10.1, from mouse

Synonym(s):

Protein numb homolog, h-Numb, S171

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Numb Antibody, clone 6G10.1, clone 6G10.1, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6G10.1, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_001005743

UniProt accession no.

P49757

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... NUMB(8650)

Analysis Note

Control
A431 cell lysate

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Numb in 10 µg of A431 cell lysate.

Application

Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.

Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Numb in HeLa and A431 cells.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Biochem/physiol Actions

This antibody recognizes Numb isoforms 1 and 2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Numb plays a key role in neurogenesis and in cell fate decisions. It maintains self-renewal properties in neural progenitor cells, which are also called radial glial cells (RGCs). It functions through inhibition of Notch signaling. Additionally, it is suggested to mediate local repair in brain ventricular wall damage.

~70 kDa observed. Uniprot describes four isoforms at ~71 kDa (isoform 1), ~66 kDa (isoform 2), ~69 kDa (isoform 3), and ~65 kDa (isoform 4).

Immunogen

KLH-conjugated linear peptide corresponding to human Numb isoforms 1 and 2.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c