Anti-SV2C Antibody, clone 4C8.1

The protein named Synaptic vesicle glycoprotein 2C (SV2C) and encoded by the human name named SV2C/KAA1054 is glycosylated membrane bound protein important in vesicle secretion. SV2C is part of the major facilitator superfamily of vesicle movement and fusion proteins and is particularly important is vesicle fusion by maintaining a readily releasable pool of secretory granules. Expressed in neural and endocrine cells primarily, SV2C is important for neurotransmission and hormone release. SV2C is enriched in small synaptic vesicles and adrenal microsomes but it is not present in chromaffin granules but is found in insulin granules and microvesicles in the pancreas. In the brain SV2C, in contrast to SV2A and SV2B, expression is restricted to certain regions. High levels of SV2C are found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem and the olfactory bulb, but SV2C is undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex. Recent research though also demonstrates that SV2C plays an important role in normal operation of the basal ganglia network and SV2C could also be involved in system adaptation during basal ganglia pathology.

~82 kDa observed

Epitope: Cytoplasmic domain

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human SV2C.

Anti-SV2C Antibody, clone 4C8.1 is a highly specific mouse monoclonal antibody, that targets SV2C & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SV2C in human cerebellum and human thalamus tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected SV2C in 200 µg of mouse brain tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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