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Merck

MABN46

Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1

clone CPTC-CLIC1, from mouse

Synonym(s):

chloride intracellular channel 1, Chloride channel ABP, RNCC protein, Nuclear chloride ion channel 27, nuclear chloride ion channel protein, Regulatory nuclear chloride ion channel protein, chloride intracellular channel protein 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CPTC-CLIC1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001279

UniProt accession no.

O00299

shipped in

wet ice

Gene Information

human ... CLIC1(1192)

General description

Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression.
~27 kDa observed

Immunogen

Full length recombinant protein corresponding to human CLIC1.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.

Application

Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 detects level of Chloride intracellular channel protein (CLIC1) & has been published & validated for use in WB, IH.
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-CLIC1-2)
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

Physical form

Format: Purified
Protein G
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human liver tissue lysate
Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.25 µg/mL of this antibody detected CLIC1 on 10 µg of human liver tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mahamud-Ur Rashid et al.
Journal of cellular physiology, 234(6), 7718-7724 (2018-12-06)
Serum starvation is a widely used condition in molecular biology experiments. Opti-MEM is a serum-reduced media used during transfection of genetic molecules into mammalian cells. However, the impact of such media on cell viability and protein synthesis is unknown. A549
Bo Liu et al.
Physiological reports, 6(2) (2018-01-26)
Chloride channels are known to play critical physiological roles in many cell types. Here, we describe the expression of anion channels using RNA Seq in primary cultures of human bronchial epithelial cells (hBECs). Chloride intracellular channel (CLIC) family members were
Mahamud-Ur Rashid et al.
Frontiers in microbiology, 13, 994512-994512 (2022-10-28)
Newly re-emerging viruses are of significant global concern. In late 2019, a new coronavirus, SARS-CoV-2, emerged in China and soon spread worldwide, causing the COVID-19 pandemic, which to date has caused >6 M deaths. There has been a wealth of studies

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