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Merck

MABN641

Anti-TMEM16B Antibody, clone 7H10

clone 7H10, from mouse

Synonym(s):

Anoctamin-2, Transmembrane protein 16B

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-TMEM16B Antibody, clone 7H10, clone 7H10, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

7H10, monoclonal

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_065106

UniProt accession no.

Q9NQ90

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ANO2(57101)

Application

Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Anti-TMEM16B Antibody, clone 7H10 is a highly specific mouse monoclonal antibody, that targets TMEM16B & has been tested in IHC, western blotting & ICC.
Western Blotting Analysis: A representative lot detected TMEM16B in 293-EBNA cell lysates overexpressing TMEM16B and in mouse retina and brain homogenates (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).
Immunocytochemistry Analysis: A representative lot detected TMEM16B in mouse retina cells (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).

Analysis Note

Evaluated by Immunohistochemistry in mouse retina tissue.

Imunnohistochemistry Analysis: A 1:50 dilution of this antibody detected TMEM16B in mouse retina tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

114 kDa calculated
The protein named Anoctamin-2 or alternatively Transmembrane protein 16B and encoded by the human gene ANO2/C12orf3/TMEM16B is a calcium activated chloride channel that plays a role in smell or olfactory signal transduction and photoreception. Odorant molecules bind to odor-sensing receptors leading to an increase in calcium entry that then activates TMEM16B calcium current which amplifies the depolarization of the Odor-sensing receptors. TEMEM16B also mediates light perception amplification in the retina where TMEM16B is a component of the presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. TEMEM16B is expressed in sensory neurons particularly in the retina and olfactory neurons; it localizes to the plasma membrane where it is a multi-pass membrane bound protein. TEMEM16B has multiple isoforms and recent research suggest that the native channel may be composed of two or more splicing isoforms acting as subunits that together shape the channel properties.

Immunogen

Epitope: N-terminus
GST-tagged recombinant protein corresponding to the N-terminus of human TMEM16B.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Julia Steiger et al.
Journal of immunology (Baltimore, Md. : 1950), 197(1), 222-232 (2016-05-29)
Glucocorticoids are extensively used to treat inflammatory diseases; however, their chronic intake increases the risk for mycobacterial infections. Meanwhile, the effects of glucocorticoids on innate host responses are incompletely understood. In this study, we investigated the direct effects of glucocorticoids

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Global Trade Item Number

SKUGTIN
MABN64104053252934964

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