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Merck

MABN650

Anti-Kirrel3 Antibody, short isoform 3, clone N320/48

clone N320/48, from mouse

Synonym(s):

Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, Processed kin of IRRE-like protein 3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Kirrel3 Antibody, short isoform 3, clone N320/48, clone N320/48, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N320/48, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001177840

UniProt accession no.

Q8BR86-3

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KIRREL3(84623)

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Kirrel3, short isoform 3 in 10 µg of human brain tissue lysate.

Application

Detect Kin of IRRE-like protein 3 using this mouse monoclonal antibody, Anti-Kirrel3 Antibody, short isoform 3, clone N320/48 validated for use in western blotting & IHC.
Western Blotting Analysis: A representative lot detected Kirrel3, short isoform 3 in COS cell lysates transiently transfected with Kirrel3, short form, and demonstrated a loss of signal in COS cell lyasates transiently transfected with Kirrel3, long form or with untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.).
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Kirrel3, short isoform 3 in human thalamus and human bone marrow tissue.

Biochem/physiol Actions

This antibody recognizes the cytoplasmic domain of Kirrel3, short isoform 3 and does not cross-react with other Kirrel3 isoforms.

General description

Kin of IRRE-like protein 3 (Kirrel3) or Kin of irregular chiasm-like protein 3 is expressed primarily in adult brain, bone marrow and stromal cells. Kirrel3 is thought to be involved in the hematopoietic supportive capacity of stroma cells, and the secreted extracellular domain of Kirrel3 is directly responsible for supporting hematopoietic stem cells.
~ 75 kDa observed

Immunogen

Linear peptide corresponding to the cytoplasmic domain of mouse Kirrel3, short isoform 3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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