MABN653

Anti-Nalcn Antibody, clone N185/7

Name: Anti-Nalcn Antibody, clone N185/7
Brand: MM

clone N185/7, from mouse

Synonym(s):

Sodium leak channel non-selective protein, Four domain-type voltage-gated ion channel alpha-1 subunit, Voltage gated channel-like protein 1

Select a Size

All Photos(2)

About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N185/7, monoclonal

species reactivity

human

species reactivity (predicted by homology)

rat (based on 100% sequence homology)

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_705894

UniProt accession no.

Q6Q760

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... NALF1(728215)

General description

Sodium leak channel non-selective protein (NALCN) is also called Four domain-type voltage-gated ion channel alpha-1 subunit and Voltage gated channel-like protein 1 (Vgcnl1). NALCN is a voltage-independent, cation-nonselective channel which transports sodium, potassium and calcium ions. NALCN maintains the background sodium ion leak current in neurons, controls neuronal excitability and is essential for normal respiratory rhythm and neonatal survival. NALCN is activated by substance P or neurotensin, and is mainly expressed in the brain or to a lesser extent, heart and pancreas.

~ 200 kDa observed

Immunogen

Epitope: C terminal cytoplasmic domain

Recombinant protein corresponding to the C terminal cytoplasmic domain of rat Nalcn.

Application

Anti-Nalcn Antibody, clone N185/7 is a highly specific mouse monoclonal antibody & that targets Sodium leak channel non-selective protein & has been tested in western blotting.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Nalcn in rat brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Biochem/physiol Actions

This antibody recognizes the C terminal cytoplasmic domain of Nalcn.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in human hippocampus membrane tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Nalcn in 10 µg of human hippocampus membrane tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)