MABS1161

Anti-PYCR1 Antibody, clone 2D9.1

Name: Anti-PYCR1 Antibody, clone 2D9.1
Brand: MM

clone 2D9.1, from mouse

Synonym(s):

Pyrroline-5-carboxylate reductase 1, mitochondrial, PYCR1, P5C reductase 1, P5CR 1

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

2D9.1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_001269209

UniProt accession no.

P32322

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PYCR1(5831)

General description

Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2; UniProt P32322; also known as P5C reductase 1, P5CR 1) is encoded by the PYCR1 (also known as ARCL2B, ARCL3B) gene (Gene ID 5831) in human. Pyrroline-5-carboxylate (P5C) reductase (PYCR1) is a mitochondrial enzyme that utilizes NAD(P)H as cofactor and catalyzes the convertion of P5C to L-proline, as well as the coversion of Δ1-piperideine-6-carboxylate (P6C) to L-pipecolic acid, both of which are intermediates in the catabolism pathway of the essential amino acid L-lysine. PYCR1 gene mutations are associated with the autosomal recessive disorder cutis laxa type II, menifested with premature aging features such as joint laxity and wrinkled/lax skin, as well as developmental delay.

~33 kDa observed. 33.36 kDa (isoform 1) and 35.98 kDa (isoform 2) calculated. Uncharacterized band(s) may appear in some lysates. Uncharacterized band(s) may appear in some lysates.

Immunogen

GST-tagged recombinant protein corresponding to the C-terminal of human PYCR1.

Application

Anti-PYCR1 Antibody, clone 2D9.1 is an antibody against PYCR1 for use in Western Blotting, Immunohistochemistry (Paraffin).

Biochem/physiol Actions

Expected to react with spliced isoforms 1 and 3, but not isoform 2, reported by UniProt P32322).

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected PYCR1 in 10 µg of K562 cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)