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Merck

MABT332

Anti-Obscurin Antibody, clone 4A8

clone 4A8, from mouse

Synonym(s):

Obscurin, Obscurin-RhoGEF, Obscurin-myosin light chain kinase, Obscurin-MLCK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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Product Name

Anti-Obscurin Antibody, clone 4A8, clone 4A8, from mouse

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

4A8, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

human (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001092093

UniProt accession no.

Q5VST9

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... OBSCN(84033)

Analysis Note

Evaluated by Immunohistochemistry in rat skeletal muscle tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Obscurin in rat skeletal muscle tissue.

Application

This Anti-Obscurin antibody is validated for use in WB, IH(P) for the detection of Obscurin.
Western Blotting Analysis: A representative lot detected Obscurin in extracts of adult rat quadriceps tissue lysate (Bowman, A.L., et al. (2007). FEBS Letters. 581:1549-1554).
Immunohistochemistry by fluorescent Analysis: A representative lot detected Isocitrate dehydrogenase in rat muscle tissue at resting stage (Bowman, A.L., et al. (2007). FEBS Letters. 581:1549-1554).

General description

800 kDa calculated
Obscurin, also known as Obscurin-RhoGEF or Obscurin-myosin light chain kinase, is encoded by the gene name OBSCN. Obscurin is involved in myofibrillogenesis and the assembly of myosin into sarcomeric A bands in striated muscle. Obscurin isoform 3 plus ANK1 isoform Mu17/Ank1.5 may be molecular link between the sarcoplasmic reticulum and myofibrils.

Immunogen

GST-tagged recombinant protein corresponding to the N-terminus of human Obscurin.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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