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Merck

MABT51

Anti-Galectin-3 Antibody, clone M3/38

clone M3/38, from rat

Synonym(s):

lectin, galactoside-binding, soluble, 3, Mac-2 antigen, Carbohydrate-binding protein 35, galectin-3, Galactose-specific lectin 3, Laminin-binding protein, Lectin L-29, IgE-binding protein, Galactoside-binding protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
M3/38, monoclonal
Application:
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
mouse, human
Citations:
6
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
P16110

Key Documents

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Product Name

Anti-Galectin-3 Antibody, clone M3/38, clone M3/38, from rat

biological source

rat

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

M3/38, monoclonal

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001139425

UniProt accession no.

P16110

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LGALS3(3958)

Analysis Note

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1:50,000 dilution of this antibody detected Galectin-3 in 10 µg of HeLa cell lysate.

Application

Anti-Galectin-3 Antibody, clone M3/38 is an antibody against Galectin-3 for use in WB, IP, IH & IC.
Western Blot Analysis: 1:50,000 dilution from a previous lot detected Galectin-3 in 10 µg of NIH/3T3 cell lysate.

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Springer, T., et al. (1981). THE JOURNAL OF BIOLOGICACHLE MISTRY. 256(8):3833-3839.)

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Gasbarri, A., et al. (1999). Journal of Clinical Oncology. 17(11):3494-3502.)

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Gasbarri, A., et al. (1999). Journal of Clinical Oncology. 17(11):3494-3502.)

General description

Galectin-3 belongs to the galectin gene family defined by the specificity of a carbohydrate recognition domain (CRD) for Gal/Lac and expression is usually elevated in a wide range of neoplastic cell types. The galectin CRD consists of 135 amino acids. Galectin-3 has been shown to effect tumor development and progression.
~28 kDa observed

Immunogen

Plasma membrane glycoproteins corresponding to mouse Galectin-3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Juan García-Revilla et al.
Acta neuropathologica, 146(1), 51-75 (2023-05-19)
Parkinson's Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB.
Jie-Jen Lee et al.
International journal of endocrinology, 2021, 5583491-5583491 (2021-05-27)
Accumulating evidence suggests that galectin-3 is a histologic marker of thyroid cancer. However, the pharmacological lectin-based approach has not been well studied. In the present study, we aimed to investigate the therapeutic potential of novel galectin-3 inhibitors by treating thyroid
Martijn J C van der Lienden et al.
International journal of molecular sciences, 22(5) (2021-04-04)
The lysosomal storage disease Niemann-Pick type C (NPC) is caused by impaired cholesterol efflux from lysosomes, which is accompanied by secondary lysosomal accumulation of sphingomyelin and glucosylceramide (GlcCer). Similar to Gaucher disease (GD), patients deficient in glucocerebrosidase (GCase) degrading GlcCer
Malene Laage Ebstrup et al.
Frontiers in cell and developmental biology, 11, 1211498-1211498 (2024-02-13)
Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently
Kevin Burbidge et al.
Autophagy, 18(5), 1020-1048 (2021-10-07)
Numerous lines of evidence support the premise that the misfolding and subsequent accumulation of SNCA/α-synuclein (synuclein alpha) is responsible for the underlying neuronal pathology observed in Parkinson disease (PD) and other synucleinopathies. Moreover, the cell-to-cell transfer of these misfolded SNCA
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Global Trade Item Number

SKUGTIN
MABT5104053252290985

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