Key Documents

COA/COQ

MABT61

Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

Name: Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302
Brand: MM

clone R1.302.12, from mouse

Synonym(s):

poliovirus receptor-related 1 (herpesvirus entry mediator C), nectin-1, poliovirus receptor-related protein 1, poliovirus receptor-like 1, nectin 1, ectodermal dysplasia 4 (Margarita Island type), Herpesvirus entry mediator C, Herpes virus entry mediator

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

R1.302.12, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
immunofluorescence: suitable

isotype

IgG1κ

NCBI accession no.

NP_002846

UniProt accession no.

Q15223

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PVRL1(5818)

General description

57 kDa calculated

Nectin-1, also known as poliovirus receptor-related protein 1 (PRR1 or PVRL1) or CD111, is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectins are known for being the receptors for the herpes simplex virus. Nectin-1 is connected with the actin cytoskeleton through afadin inside the cell. It is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-1 seems to adhere primarily to cells expressing nectin-4 and vice versa.

Immunogen

Human CD111 transfected NIH/3T3 cells

Application

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Cocchi, F., et al. (1998). Journal of Virology. 72(12):9992–10002).

This Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302 is validated for use in FC, IF for the detection of Nectin-1/PVRL1 (CD111).

Physical form

Format: Purified

Analysis Note

Control
Human TF-1 cells

Evaluated by Flow Cytometry in human TF-1 cells.

Flow Cytometry Analysis: 0.25 µg of this antibody detected Nectin-1/PVRL1 in human TF-1 cells.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate.

Kristin L M Boylan et al.

Oncotarget, 8(6), 9717-9738 (2016-12-31)

The cell adhesion molecule Nectin-4 is overexpressed in epithelial cancers, including ovarian cancer. The objective of this study was to determine the biological significance of Nectin-4 in the adhesion, aggregation, migration, and proliferation of ovarian cancer cells. Nectin-4 and its

Global Trade Item Number

SKU	GTIN
MABT61	04053252681837

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