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MABT78

Sigma-Aldrich

Anti-mouse CD44 (H-CAM) Antibody, clone KM201

clone KM201, from rat

Synonym(s):

CD44 antigen (homing function and Indian blood group system), CDw44 antigen, HCAM, H-CAM, HUTCH-1, Phagocytic glycoprotein I, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, Heparan sulfate proteoglycan, Hermes antigen, Hyalu

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

KM201, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NP_001034240

UniProt accession no.

P15379

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CD44(960)

General description

86 kDa calculated
CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.

Immunogen

Epitope: Near the hyaluronate binding domain
Mouse bone marrow-derived stromal cells

Application

Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
Research Category
Cell Structure

Stem Cell Research
Research Sub Category
Adhesion (CAMs)

Hematopoietic Stem Cells

Biochem/physiol Actions

The antibody recognizes CD44 near the hyaluronate binding domain.

Physical form

Format: Purified
Protein G
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse bone marrow cells
Evaluated by Flow Cytometry in mouse bone marrow cells.

Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: CBL1308

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Giuseppe M Campo et al.
Innate immunity, 19(5), 462-478 (2013-01-04)
Investigations have suggested degradation of native hyaluronan (HA) into small oligosaccharides as being involved in the development and progression of inflammatory diseases, particularly rheumatoid arthritis (RA). Inflammatory responses occur by modulating the TLR4 and 2, and the CD44 natural HA
Monserrat Gerardo-Ramírez et al.
Cells, 12(9) (2023-05-13)
Primary liver cancer is the third leading cause of cancer-related death worldwide. An increasing body of evidence suggests that the Hippo tumor suppressor pathway plays a critical role in restricting cell proliferation and determining cell fate during physiological and pathological

Global Trade Item Number

SKUGTIN
MABT7804053252746642

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