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Merck

MGAMMAG-300K

MILLIPLEX® Mouse Immunoglobulin Isotyping Panel

Configurable Mouse Immunoglobulin Isotyping 6-Plex Panel

Synonym(s):

Luminex® Mouse Isotyping Assay, Millipore Mouse Isotyping Assay, Mouse IgG, IgA, IgM immunoassay, Mouse Isotyoing Multiplex Assay

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Mouse Immunoglobulin Isotyping Panel, Configurable Mouse Immunoglobulin Isotyping 6-Plex Panel

species reactivity

mouse

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 100%
(IgM)
accuracy: 85%
(IgG3)
accuracy: 98%
(IgA)
accuracy: 98%
(IgG2b)
sensitivity: 0.18 ng/mL
(IgG2b)
sensitivity: 0.32 ng/mL
(IgG3)
sensitivity: 0.67 ng/mL
(IgG2a)
sensitivity: 0.7 ng/mL
(IgG1)
sensitivity: 1.1 ng/mL
(IgA)
sensitivity: 1.73 ng/mL
(IgM)
standard curve range: 1-900 ng/mL
(IgG2b)
standard curve range: 2-1,500 ng/mL
(IgG1)
standard curve range: 2-1,500 ng/mL
(IgG3)
standard curve range: 2-1,500 ng/mL
(IgM)
standard curve range: 3-2,000 ng/mL
(IgG2a)
standard curve range: 5-3,000 ng/mL
(IgA)
inter-assay cv: 14-17%
intra-assay cv: 5-10%

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)
tissue/cellular lysate

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Other Notes

Replaces: MGAM-300

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in mouse serum, tissue/cell lysates, and cell culture supernatants.

Analytes included: IgM, IgG1, IgG2a, IgG2b, IgG3, IgA

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Comprehensive Isotype Profiling: Measures six major mouse immunoglobulin isotypes: IgG1, IgG2a, IgG2b, IgG3, IgA, and IgM—all in a single well.

Flexible Panel Design: Choose only the immunoglobulins relevant to your study, allowing for customized assay configurations.

High Dilution Compatibility: Optimized for 1:50,000 dilution, enabling accurate quantification even in highly concentrated samples.

Fast Assay Turnaround: Complete your assay in one day, streamlining workflows and accelerating data collection.

Support Disease Characterization: Ideal for studying autoimmune disorders, GI conditions, and malignancies where isotype imbalances are key indicators.

Enhance Experimental Efficiency: Multiplex format boosts productivity while conserving sample volume—especially valuable in small animal studies.

General description

Produced by plasma cells and lymphocytes, immunoglobulins (antibodies) are critically involved in immune response, attaching to antigens, and playing a role in their destruction. Immunoglobulins (Ig) can be classified by isotype, classes that differ in function and antigen response due to structure variability. Six major isotypes have been identified in placental mammals: IgM, IgG1, IgG2a, IgG2b, IgG3 and IgA – all found in normal individuals. Immunoglobulin-deficiency disorders, such as autoimmune disease, some GI conditions, and malignancies, are characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of immunoglobulin classes.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10.
Chen, Y; Zhang, J; Hwang, KK; Bouton-Verville, H; Xia, SM; Newman, A; Ouyang, YB; Haynes et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Tao Huang et al.
JCI insight, 1(7), e86689-e86689 (2016-10-05)
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single Th2 cytokines have shown benefits in subsets of biomarker-positive patients. More broadly effective treatment or disease-modifying effects may be achieved
Bart G Jones et al.
International immunology, 31(3), 141-156 (2018-11-09)
Nuclear hormone receptors including the estrogen receptor (ERα) and the retinoic acid receptor regulate a plethora of biological functions including reproduction, circulation and immunity. To understand how estrogen and other nuclear hormones influence antibody production, we characterized total serum antibody
Mara A Correa et al.
BioMed research international, 2018, 1267038-1267038 (2018-11-08)
Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense
Sungwoo Chei et al.
Frontiers in nutrition, 7, 583186-583186 (2020-12-18)
Anti-aging research suggests that immunosenescent cells can play deleterious roles in the immune system. Here, young (2 months old) and old (14 months old) C57BL/6 mice received a daily oral dose (100 or 750 mg/kg/day) of acid-hydrolyzed silk peptide (SP)
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Quality Control Range Sheet- MIG-16K
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Global Trade Item Number

SKUGTIN
MGAMMAG-300K-0204053252801341
MGAMMAG-300K-0304053252801358
MGAMMAG-300K-03C04055977105698
MGAMMAG-300K-0104053252801334
MGAMMAG-300K-0504053252801372
MGAMMAG-300K-0604053252801389
MGAMMAG-300K-01C04055977107470
MGAMMAG-300K-02C04055977102420
MGAMMAG-300K-06C04055977102444
MGAMMAG-300K-04C04055977102437
MGAMMAG-300K-0404053252801365
MGAMMAG-300K-05C04055977105704

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