DGTP-RO

Roche

dGTP

Name: dGTP
Brand: ROCHE

PCR Grade, sodium salt

Synonym(s):

2′-Deoxyguanosine 5′-triphosphate trisodium salt solution, dGTP-Na₃

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃N₅Na₃O₁₃P₃

CAS Number:

93919-41-6

Molecular Weight:

573.13

UNSPSC Code:

12352302

PubChem Substance ID:

329798919

MDL number:

MFCD00080337

NACRES:

NA.54

Product Name

dGTP, PCR Grade, sodium salt

InChI

1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1

SMILES string

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1

InChI key

IWGGLKOTEOCWQP-BIHLCPNHSA-K

assay

99% (dNTP)

form

solution

usage

sufficient for 125,000 standard reactions (03732703001)
sufficient for 31,250 standard reactions (11969030001)
sufficient for 6,250 standard reactions (11934538001)

packaging

pkg of 1,250 μL (11969030001 [100 mM])
pkg of 4 × 1,240 μL (03732703001 [4x100 mM])
pkg of 250 μL (11934538001 [100 mM])

manufacturer/tradename

Roche

concentration

<0.9% (dNDP)
100 mM

storage temp.

−20°C

Quality Level

100

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Analysis Note

Function tested in RT-PCR. Tested for absence of contaminating deoxyribonucleases, ribonucleases and nicking activities according to the current Quality Control procedures.

Application

2′-Deoxyguanosine 5′-triphosphate trisodium salt is utilized for methods such as DNA sequencing, PCR and other DNA polymerase based DNA synthesis and repair techniques.

General description

2′-Deoxyguanosine 5′-triphosphate (dGTP) is made of a guanine nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar linked to a chain of three phosphate residues. It is used by the cells for the synthesis of DNA with the help of DNA polymerase.

dGTP, PCR Grade, is a 100 mM clear, colorless solution of the sodium salt (pH 8.3). PCR Grade nucleotides from Roche are specially manufactured and purified to the highest possible chemical purity. PCR Grade nucleotides contain at least 99% of the relevant deoxynucleoside-triphosphate (dNTP) and less than 0.9% deoxynucleoside-diphosphate (dNDP).

Other Notes

For general laboratory use.

Physical form

solution of dGTP in water (pH 8.3).

Preparation Note

Working solution: We recommend to prepare a deoxynucleotide mix containing dATP, dCTP, dGTP, dTTP (10 mM, each); (e.g., for the preparation of 100 μl nucleotide mix add 10 μl of dATP, dCTP, dGTP, dTTP (each) to 60 μl Water, PCR Grade).

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

does not flash

flash_point_c

does not flash

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Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene.

Elin L Aschim et al.

The Journal of clinical endocrinology and metabolism, 89(10), 5105-5109 (2004-10-09)

Although sufficient androgen receptor (AR) function is crucial for normal male sexual differentiation, single-point mutations in the AR gene are infrequent in the two most common male congenital malformations, hypospadias and cryptorchidism. Because polymorphic CAG and GGN segments regulate AR