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Merck

70221

Ammonium formate

eluent additive for LC-MS, LiChropur™, ≥99.0%

Synonym(s):

Formic acid ammonium salt

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About This Item

Linear Formula:
HCO2NH4
CAS Number:
540-69-2
Molecular Weight:
63.06
NACRES:
NB.21
PubChem Substance ID:
329762353
eCl@ss:
39021903
UNSPSC Code:
12352107
EC Number:
208-753-9
MDL number:
MFCD00013103
Beilstein/REAXYS Number:
3625095

Product Name

Ammonium formate, eluent additive for LC-MS, LiChropur™, ≥99.0%

InChI key

VZTDIZULWFCMLS-UHFFFAOYSA-N

InChI

1S/CH2O2.H3N/c2-1-3;/h1H,(H,2,3);1H3

SMILES string

N.OC=O

description

anionic

Quality Level

100

product line

LiChropur™

assay

≥99.0% (calc. on dry substance, NT)
≥99.0%

form

crystals

quality

LiChropur™

technique(s)

LC/MS: suitable

impurities

insoluble matter, passes filter test
<2% water

ign. residue (900°C)

<0.1% (as SO4)

pH

5.5-7.5 (25 °C, 1 M in H2O)

mp

119-121 °C (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

density

1.26 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤1 mg/kg
As: ≤0.1 mg/kg
Ba: ≤1 mg/kg
Bi: ≤1 mg/kg
Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤5 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Mo: ≤1 mg/kg
Na: ≤5 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.01
λ: 280 nm Amax: ≤0.01

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Application

Ammonium formate has been used as buffer solution during LC-MS/MS analysis for screening of drugs and exogenous compounds. It may be used as a catalytic hydrogen transfer agent in reduction of aliphatic and aromatic nitro compounds.
Ammonium formate has been used in the separation of non-steroidal anti-inflammatory drugs and of oligosaccharide mixtures using capillary electrochromatography. It is also used in the analysis of phosphatidylserines, triacylglycerols and triacylglycerol oxidation products, and oligogalacturonic acids using HPLC and HPLC-MS methods.
Ammonium formate has been used as buffer solution during LC-MS/MS analysis for screening of drugs and exogenous compounds. It may be used as a catalytic hydrogen transfer agent in reduction of aliphatic and aromatic nitro compounds.

General description

Ammonium formate is the ammonium salt of formic acid. It is readily available, is stable and nontoxic in nature. It can be used in conjugation with Palladium on carbon (Pd-C) or Raney-Nickel catalysts.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8926
0000451196
0000451196
0000470755
0000462363

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François-Ludovic Sauvage et al.
Clinical chemistry, 52(9), 1735-1742 (2006-07-22)
In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a comprehensive general unknown screening method based on liquid chromatography coupled with a hybrid triple-quadrupole linear ion
Nara Liessi et al.
JCI insight, 5(16) (2020-07-17)
In recent years, a number of drugs have been approved for the treatment of cystic fibrosis (CF). Among them, newly released Trikafta, a combination of 3 drugs (VX-661/VX-445/VX-770), holds great promise to radically improve the quality of life for a
A general procedure for mild and rapid reduction of aliphatic and aromatic nitro compounds using ammonium formate as a catalytic hydrogen transfer agent.
Ram, Siya, and Richard E. Ehrenkaufer.
Tetrahedron Letters, 25.32, 3415-3418 (1984)
Lin Wang et al.
Annals of palliative medicine, 10(4), 4354-4368 (2021-05-11)
To explore the role of intestinal flora in seborrhea, non-targeted metabolomics analysis was carried out. Fecal samples were collected from 5 seborrheic patients and 5 healthy controls from October 2019 to April 2020. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry
Jiang-Tao Niu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 4543761-4543761 (2020-12-22)
To compare the changes of chemical components of Hedysari Radix (HR) before and after honey-processing, and to explore the material basis of the difference between HR and honey-processed Hedysari Radix (HPHR) in Buzhong Yiqi. Different compounds in aqueous extracts of
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