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D3168

Duramycin from Streptoverticillium cinnamoneus

≥90.0%

Synonym(s):

Duramycin, Lancovutide

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About This Item

Empirical Formula (Hill Notation):
C89H125N23O25S3
CAS Number:
1391-36-2
Molecular Weight:
2013.28
UNSPSC Code:
51102829
NACRES:
NA.85
MDL number:
MFCD00133301
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Quality Segment

200

assay

≥90.0%

form

powder

solubility

0.1 M HCl: 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

General description

Chemical structure: tetracycline

Application

Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.

Biochem/physiol Actions

Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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