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116815 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem

A cell-permeable cAMP analog that binds cAMP-receptor proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA

Primary Target: cAMP-receptor proteins
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116815
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
71774-13-5C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH

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116815-10UMOL
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      Description
      OverviewA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.
      Note: 10 µmol = 4.47 mg.
      Catalogue Number116815
      Brand Family Calbiochem®
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
      References
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
      Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
      Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
      Product Information
      CAS number71774-13-5
      ATP CompetitiveN
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormCrystalline solid
      Hill FormulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetcAMP-receptor proteins
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      116815

      References

      Reference overview
      Kawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
      Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
      Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-October-2007 JSW
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
      DescriptionA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λmax = 258 nm; εmax = 15,000 M-1cm-1 (pH 7..0).
      FormCrystalline solid
      CAS number71774-13-5
      Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
      Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
      Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.