Millipore Sigma Vibrant Logo

MABC545 Anti-FANCM Antibody, clone CV5.1

Detect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.

Anti-FANCM Antibody, clone CV5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Apoptosis - Additional Gene Symbol: FANCM UniProt Number: Q8IYD8
View Products on Sigmaaldrich.com
MABC545
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC545
      DescriptionAnti-FANCM Antibody, clone CV5.1
      Alternate Names
      • Fanconi anemia group M protein
      • Protein FACM
      • ATP-dependent RNA helicase FANCM
      • Fanconi anemia-associated polypeptide of 250 kDa
      • FAAP250
      • Protein Hef ortholog
      Background InformationFANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human FANCM.
      CloneCV5.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FANCM
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight230 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry Analysis in A431, HeLa, and HepG2 cells.

      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.

      Dylight® is a registered trademark of Thermo Fisher Scientific.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC545 04053252976315

      Documentation

      Anti-FANCM Antibody, clone CV5.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-FANCM Antibody, clone CV5.1 Certificates of Analysis

      TitleLot Number
      Anti-FANCM, clone CV5.1 - Q2430181 Q2430181
      Anti-FANCM, clone CV5.1 - 3317044 3317044
      Anti-FANCM, clone CV5.1 - 3528118 3528118
      Anti-FANCM, clone CV5.1 - 3837102 3837102
      Anti-FANCM, clone CV5.1 - 3944863 3944863
      Anti-FANCM, clone CV5.1 - 4094546 4094546
      Anti-FANCM, clone CV5.1 - 4269355 4269355
      Anti-FANCM, clone CV5.1 -2698513 2698513
      Anti-FANCM, clone CV5.1 Monoclonal Antibody 3153206